Seroatlas · Human Serome Atlas

HVCN1

Voltage-gated hydrogen channel 1

Also known as: Hv1, HVCN1_HUMAN, MGC15619, VSOP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96D96
Gene
HVCN1
Ensembl
ENSG00000122986
Chromosome
12
Canonical length
273 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q96D96|HVCN1
     1  MATWDEKAVT RRAKVAPAER MSKFLRHFTV VGDDYHAWNI NYKKWENEEE EEEEEQPPPT
    61  PVSGEEGRAA APDVAPAPGP APRAPLDFRG MLRKLFSSHR FQVIIICLVV LDALLVLAEL
   121  ILDLKIIQPD KNNYAAMVFH YMSITILVFF MMEIIFKLFV FRLEFFHHKF EILDAVVVVV
   181  SFILDIVLLF QEHQFEALGL LILLRLWRVA RIINGIIISV KTRSERQLLR LKQMNVQLAA
   241  KIQHLEFSCS EKEQEIERLN KLLRQHGLLG EVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HVCN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
505 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 505 nTPM
  • tonsil: 68 nTPM
  • lymph node: 61 nTPM
  • testis: 42 nTPM
  • spleen: 40 nTPM
  • midbrain: 40 nTPM

Single-cell type

  • oocytes: 368 nCPM
  • choroid plexus epithelial cells: 294 nCPM
  • late primary spermatocytes: 217 nCPM
  • b-cells: 209 nCPM
  • pdcs: 118 nCPM
  • cardiomyocytes: 105 nCPM

Immune cell

  • naive B-cell: 803 nTPM
  • eosinophil: 677 nTPM
  • memory B-cell: 553 nTPM
  • basophil: 380 nTPM
  • neutrophil: 329 nTPM
  • classical monocyte: 209 nTPM

Brain region

  • choroid plexus: 319 nTPM
  • basal ganglia: 52 nTPM
  • midbrain: 50 nTPM
  • hypothalamus: 43 nTPM
  • pons: 39 nTPM
  • thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.63
gnomAD missense Z
1.34
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HVCN1 as an antibody target. Whether an autoantibody or antibody against HVCN1 could matter depends on whether native HVCN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HVCN1 is annotated at the cell surface, where native HVCN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production.

Canonical record: https://seroatlas.com/gene/HVCN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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