Seroatlas · Human Serome Atlas

HTR7

5-hydroxytryptamine receptor 7

Also known as: 5-HT7, 5HT7R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P34969
Gene
HTR7
Ensembl
ENSG00000148680
Chromosome
10
Canonical length
479 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Plasma membrane,Primary cilium,Cytosol

OverviewNCBI Gene

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>P34969|HTR7
     1  MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS EVTASPAPTW
    61  DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC LVVISVCFVK KLRQPSNYLI
   121  VSLALADLSV AVAVMPFVSV TDLIGGKWIF GHFFCNVFIA MDVMCCTASI MTLCVISIDR
   181  YLGITRPLTY PVRQNGKCMA KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT
   241  IYSTAVAFYI PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE
   301  ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR PFICGTSCSC
   361  IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ CQYRNINRKL SAAGMHEALK
   421  LAERPERPEF VLRACTRRVL LRPEKRPPVS VWVLQSPDHH NWLADKMLTT VEKKVMIHD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 12 nTPM
  • testis: 8.2 nTPM
  • hypothalamus: 2.1 nTPM
  • urinary bladder: 2.1 nTPM
  • blood vessel: 1.8 nTPM
  • cerebral cortex: 1.4 nTPM

Single-cell type

  • hepatic stellate cells: 45 nCPM
  • cdc: 42 nCPM
  • macrophages: 30 nCPM
  • undifferentiated spermatogonia: 26 nCPM
  • other brain neurons: 25 nCPM
  • brain excitatory neurons: 23 nCPM

Immune cell

  • myeloid DC: 1.4 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 18 nTPM
  • hypothalamus: 16 nTPM
  • midbrain: 7.9 nTPM
  • hippocampal formation: 7.4 nTPM
  • cerebral cortex: 7.3 nTPM
  • amygdala: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.05
gnomAD missense Z
1.73
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR7 as an antibody target. Whether an autoantibody or antibody against HTR7 could matter depends on whether native HTR7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR7 is annotated at the cell surface, where native HTR7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HTR7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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