Seroatlas · Human Serome Atlas

HTR5A

5-hydroxytryptamine receptor 5A

Also known as: 5-HT5A, 5HT5A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P47898
Gene
HTR5A
Ensembl
ENSG00000157219
Chromosome
7
Canonical length
357 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>P47898|HTR5A
     1  MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL
    61  VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC
   121  DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG
   181  WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS
   241  PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP
   301  FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
4 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 4 nTPM
  • cerebral cortex: 2.1 nTPM
  • hypothalamus: 1.6 nTPM
  • basal ganglia: 0.9 nTPM
  • thymus: 0.7 nTPM
  • amygdala: 0.6 nTPM

Single-cell type

  • late spermatids: 22 nCPM
  • other brain neurons: 13 nCPM
  • brain excitatory neurons: 10 nCPM
  • brain inhibitory neurons: 9.6 nCPM
  • late primary spermatocytes: 8.7 nCPM
  • early spermatids: 7.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 11 nTPM
  • cerebral cortex: 9.9 nTPM
  • midbrain: 8.9 nTPM
  • pons: 7.4 nTPM
  • hypothalamus: 7.2 nTPM
  • basal ganglia: 6.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HTR5A.

Disease | ImmuneIEDB

Conditions an epitope on HTR5A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0.01
gnomAD missense Z
0.18
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR5A as an antibody target. Whether an autoantibody or antibody against HTR5A could matter depends on whether native HTR5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR5A is annotated at the cell surface, where native HTR5A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HTR5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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