HTR2B

Protein identityUniProt · HPA

UniProt accession

P41595

Gene

HTR2B

Ensembl

ENSG00000135914

Chromosome

2

Canonical length

481 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>P41595|HTR2B
     1  MALSYRVSEL QSTIPEHILQ STFVHVISSN WSGLQTESIP EEMKQIVEEQ GNKLHWAALL
    61  ILMVIIPTIG GNTLVILAVS LEKKLQYATN YFLMSLAVAD LLVGLFVMPI ALLTIMFEAM
   121  WPLPLVLCPA WLFLDVLFST ASIMHLCAIS VDRYIAIKKP IQANQYNSRA TAFIKITVVW
   181  LISIGIAIPV PIKGIETDVD NPNNITCVLT KERFGDFMLF GSLAAFFTPL AIMIVTYFLT
   241  IHALQKKAYL VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET
   301  LMRRTSTIGK KSVQTISNEQ RASKVLGIVF FLFLLMWCPF FITNITLVLC DSCNQTTLQM
   361  LLEIFVWIGY VSSGVNPLVY TLFNKTFRDA FGRYITCNYR ATKSVKTLRK RSSKIYFRNP
   421  MAENSKFFKK HGIRNGINPA MYQSPMRLRS STIQSSSIIL LDTLLLTENE GDKTEEQVSY
   481  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.33

gnomAD pLI

0

gnomAD missense Z

-0.13

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium-mediated signaling
• cardiac muscle hypertrophy
• cGMP-mediated signaling
• chemical synaptic transmission
• embryonic morphogenesis
• ERK1 and ERK2 cascade
• G protein-coupled receptor signaling pathway
• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• G protein-coupled serotonin receptor signaling pathway
• heart morphogenesis
• intestine smooth muscle contraction
• intracellular calcium ion homeostasis
• negative regulation of apoptotic process
• neural crest cell differentiation
• neural crest cell migration
• phospholipase C-activating serotonin receptor signaling pathway
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of cell division
• positive regulation of cell population proliferation
• positive regulation of cytokine production
• positive regulation of endothelial cell proliferation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of phosphatidylinositol biosynthetic process
• regulation of behavior
• release of sequestered calcium ion into cytosol
• response to xenobiotic stimulus
• serotonin receptor signaling pathway
• vasoconstriction

Molecular functions

• G protein-coupled serotonin receptor activity
• G-protein alpha-subunit binding
• Gq/11-coupled serotonin receptor activity
• GTPase activator activity
• neurotransmitter receptor activity
• serotonin binding
• serotonin receptor activity

Cellular components

• cytoplasm
• dendrite
• G protein-coupled serotonin receptor complex
• nucleoplasm
• plasma membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• 5-hydroxytryptamine receptor family
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• 5-Hydroxytryptamine 2B receptor

KeywordsUniProt

• Behavior
• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Lipoprotein
• Membrane
• Palmitate
• Receptor
• Synapse
• Synaptosome
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of HTR2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MPDZ