Seroatlas · Human Serome Atlas

HTR1E

5-hydroxytryptamine receptor 1E

Also known as: 5-HT1E, 5HT1E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P28566
Gene: HTR1E
Ensembl: ENSG00000168830
Chromosome: 6
Canonical length: 365 aa
Protein class: FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>P28566|HTR1E
     1  MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT KKLHQPANYL
    61  ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS VDMTCCTCSI LHLCVIALDR
   121  YWAITNAIEY ARKRTAKRAA LMILTVWTIS IFISMPPLFW RSHRRLSPPP SQCTIQHDHV
   181  IYTIYSTLGA FYIPLTLILI LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ
   241  TFCVSDFSTS DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF
   301  ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED FKLAFKKLIR
   361  CREHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

ovary: 4 nTPM
cerebral cortex: 3.5 nTPM
basal ganglia: 2.5 nTPM
endometrium: 1.4 nTPM
stomach: 1.3 nTPM
hypothalamus: 1.2 nTPM

Single-cell type

other brain neurons: 115 nCPM
brain inhibitory neurons: 107 nCPM
brain excitatory neurons: 89 nCPM
late primary spermatocytes: 78 nCPM
gastric chief cells: 67 nCPM
late spermatids: 51 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 15 nTPM
white matter: 12 nTPM
basal ganglia: 11 nTPM
hypothalamus: 8.1 nTPM
hippocampal formation: 6 nTPM
pons: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.29
gnomAD missense Z: 1.71
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR1E as an antibody target. Whether an autoantibody or antibody against HTR1E could matter depends on whether native HTR1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR1E is annotated at the cell surface, where native HTR1E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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