Seroatlas · Human Serome Atlas

HTR1D

5-hydroxytryptamine receptor 1D

Also known as: 5-HT1D, 5HT1D_HUMAN, HT1DA, HTRL, RDC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P28221
Gene: HTR1D
Ensembl: ENSG00000179546
Chromosome: 1
Canonical length: 377 aa
Protein class: FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables Gi/o-coupled serotonin receptor activity and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway and intestine smooth muscle contraction. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>P28221|HTR1D
     1  MSPLNQSAEG LPQEASNRSL NATETSEAWD PRTLQALKIS LAVVLSVITL ATVLSNAFVL
    61  TTILLTRKLH TPANYLIGSL ATTDLLVSIL VMPISIAYTI THTWNFGQIL CDIWLSSDIT
   121  CCTASILHLC VIALDRYWAI TDALEYSKRR TAGHAATMIA IVWAISICIS IPPLFWRQAK
   181  AQEEMSDCLV NTSQISYTIY STCGAFYIPS VLLIILYGRI YRAARNRILN PPSLYGKRFT
   241  TAHLITGSAG SSLCSLNSSL HEGHSHSAGS PLFFNHVKIK LADSALERKR ISAARERKAT
   301  KILGIILGAF IICWLPFFVV SLVLPICRDS CWIHPALFDF FTWLGYLNSL INPIIYTVFN
   361  EEFRQAFQKI VPFRKAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

duodenum: 8 nTPM
small intestine: 7.1 nTPM
basal ganglia: 6.2 nTPM
gallbladder: 1.3 nTPM
hypothalamus: 0.7 nTPM
amygdala: 0.5 nTPM

Single-cell type

enterocytes: 10 nCPM
prostatic club cells: 5.2 nCPM
cholangiocytes: 4 nCPM
early spermatids: 2.4 nCPM
respiratory deuterosomal cells: 2.1 nCPM
brain inhibitory neurons: 1.9 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 25 nTPM
basal ganglia: 12 nTPM
hypothalamus: 9.3 nTPM
spinal cord: 4.7 nTPM
pons: 4.2 nTPM
thalamus: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
5-hydroxytryptamine receptor family
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
5-Hydroxytryptamine 1D receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR1D as an antibody target. Whether an autoantibody or antibody against HTR1D could matter depends on whether native HTR1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR1D is annotated at the cell surface, where native HTR1D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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