Seroatlas · Human Serome Atlas

HTD2

Hydroxyacyl-thioester dehydratase type 2, mitochondrial

Also known as: HTD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P86397
Gene
HTD2
Ensembl
ENSG00000255154
Chromosome
3
Canonical length
168 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

This gene encodes a protein that localizes to the mitochondria and can function as a 3-hydroxyacyl thioester dehydratase. This gene is located just downstream of the gene for ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is conserved among animals. The upstream RPP14 gene is thought to be co-transcribed with this gene, and bicistronic transcripts may include open reading frames for both proteins. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>P86397|HTD2
     1  MFPLISSHHL WWGGLRRTVC LNLPVLTLQH FQHMHIKVGD RAELRRAFTQ TDVATFSELT
    61  GDVNPLHLNE DFAKHTKFGN TIVHGVLING LISALLGTKM PGPGCVFLSQ EISFPAPLYI
   121  GEVVLASAEV KKLKRFIAII AVSCSVIESK KTVMEGWVKV MVPEASKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 41 nTPM
  • tongue: 35 nTPM
  • liver: 14 nTPM
  • heart muscle: 12 nTPM
  • parathyroid gland: 11 nTPM
  • duodenum: 11 nTPM

Single-cell type

  • brain excitatory neurons: 14 nCPM
  • brain inhibitory neurons: 12 nCPM
  • other brain neurons: 12 nCPM
  • choroid plexus epithelial cells: 12 nCPM
  • bergmann glia: 11 nCPM
  • oligodendrocyte progenitor cells: 9.8 nCPM

Immune cell

  • eosinophil: 29 nTPM
  • memory B-cell: 28 nTPM
  • naive B-cell: 28 nTPM
  • naive CD4 T-cell: 28 nTPM
  • memory CD8 T-cell: 25 nTPM
  • NK-cell: 25 nTPM

Brain region

  • cerebellum: 18 nTPM
  • hypothalamus: 14 nTPM
  • white matter: 14 nTPM
  • basal ganglia: 13 nTPM
  • cerebral cortex: 13 nTPM
  • choroid plexus: 13 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTD2 as an antibody target. Whether an autoantibody or antibody against HTD2 could matter depends on whether native HTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HTD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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