Seroatlas · Human Serome Atlas

HSBP1L1

Heat shock factor-binding protein 1-like protein 1

Also known as: FLJ10967, HSBPL_HUMAN, MGC189743

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9JCN9
Gene
HSBP1L1
Ensembl
ENSG00000226742
Chromosome
18
Canonical length
74 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in cellular heat acclimation. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

74 residues, UniProt reviewed canonical sequence.

>C9JCN9|HSBP1L1
     1  MDVRGPEAPG GRALRDAAEN LFQELQEHFQ ALTATLNLRM EEMGNRIEDL QKNVKDLMVQ
    61  AGIENSIKEQ MLKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSBP1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 39 nTPM
  • liver: 33 nTPM
  • kidney: 23 nTPM
  • cerebellum: 22 nTPM
  • adrenal gland: 21 nTPM
  • esophagus: 21 nTPM

Single-cell type

  • esophageal apical cells: 743 nCPM
  • syncytiotrophoblasts: 152 nCPM
  • hepatocytes: 149 nCPM
  • esophageal suprabasal cells: 145 nCPM
  • colonocytes: 145 nCPM
  • cytotrophoblasts: 145 nCPM

Immune cell

  • basophil: 31 nTPM
  • naive CD4 T-cell: 26 nTPM
  • naive CD8 T-cell: 14 nTPM
  • memory CD4 T-cell: 10 nTPM
  • eosinophil: 8.6 nTPM
  • MAIT T-cell: 6.9 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • thalamus: 12 nTPM
  • cerebellum: 12 nTPM
  • pons: 11 nTPM
  • medulla oblongata: 9.5 nTPM
  • midbrain: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0.05
gnomAD missense Z
0.39
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSBP1L1 as an antibody target. Whether an autoantibody or antibody against HSBP1L1 could matter depends on whether native HSBP1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSBP1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSBP1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSBP1L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...