Seroatlas · Human Serome Atlas

HRURF

Protein HRURF

Also known as: HRURF_HUMAN, U2HR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DUH7
Gene
HRURF
Ensembl
ENSG00000288677
Chromosome
8
Canonical length
34 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in regulation of translation. Implicated in hypotrichosis 4. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

34 residues, UniProt reviewed canonical sequence.

>P0DUH7|HRURF
     1  MAQPTASAQK LVRPIRAVCR ILQIPESDPS NLRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRURF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 0.6 nTPM
  • cerebellum: 0.3 nTPM
  • colon: 0.3 nTPM
  • stomach: 0.3 nTPM
  • basal ganglia: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 21 nTPM
  • hypothalamus: 16 nTPM
  • thalamus: 13 nTPM
  • cerebellum: 9.9 nTPM
  • cerebral cortex: 9.8 nTPM
  • pons: 9.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HRURF.

Disease | AllUniProt

Conditions HRURF is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 6 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypotrichosis 4

OntologyGO

Biological processes

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRURF as an antibody target. Whether an autoantibody or antibody against HRURF could matter depends on whether native HRURF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRURF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HRURF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HRURF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...