Seroatlas · Human Serome Atlas

HRH2

Histamine H2 receptor

Also known as: HRH2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25021
Gene
HRH2
Ensembl
ENSG00000113749
Chromosome
5
Canonical length
359 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>P25021|HRH2
     1  MAPNGTASSF CLDSTACKIT ITVVLAVLIL ITVAGNVVVC LAVGLNRRLR NLTNCFIVSL
    61  AITDLLLGLL VLPFSAIYQL SCKWSFGKVF CNIYTSLDVM LCTASILNLF MISLDRYCAV
   121  MDPLRYPVLV TPVRVAISLV LIWVISITLS FLSIHLGWNS RNETSKGNHT TSKCKVQVNE
   181  VYGLVDGLVT FYLPLLIMCI TYYRIFKVAR DQAKRINHIS SWKAATIREH KATVTLAAVM
   241  GAFIICWFPY FTAFVYRGLR GDDAINEVLE AIVLWLGYAN SALNPILYAA LNRDFRTGYQ
   301  QLFCCRLANR NSHKTSLRSN ASQLSRTQSR EPRQQEEKPL KLQVWSGTEV TAPQGATDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 26 nTPM
  • heart muscle: 16 nTPM
  • stomach: 10 nTPM
  • appendix: 9.2 nTPM
  • placenta: 7.5 nTPM
  • spleen: 7.1 nTPM

Single-cell type

  • neutrophils: 601 nCPM
  • parietal cells: 161 nCPM
  • neutrophil progenitors: 149 nCPM
  • monocyte progenitors: 130 nCPM
  • monocytes: 102 nCPM
  • vascular smooth muscle cells: 90 nCPM

Immune cell

  • neutrophil: 142 nTPM
  • basophil: 106 nTPM
  • eosinophil: 42 nTPM
  • non-classical monocyte: 41 nTPM
  • classical monocyte: 36 nTPM
  • intermediate monocyte: 36 nTPM

Brain region

  • basal ganglia: 27 nTPM
  • cerebral cortex: 19 nTPM
  • white matter: 11 nTPM
  • thalamus: 8.9 nTPM
  • amygdala: 7.8 nTPM
  • hippocampal formation: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0.12
gnomAD missense Z
2.53
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HRH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRH2 as an antibody target. Whether an autoantibody or antibody against HRH2 could matter depends on whether native HRH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRH2 is annotated at the cell surface, where native HRH2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HRH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HRH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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