Seroatlas · Human Serome Atlas

HRH1

Histamine H1 receptor

Also known as: HRH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35367
Gene
HRH1
Ensembl
ENSG00000196639
Chromosome
3
Canonical length
487 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>P35367|HRH1
     1  MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY AVRSERKLHT
    61  VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC LFWLSMDYVA STASIFSVFI
   121  LCIDRYRSVQ QPLRYLKYRT KTRASATILG AWFLSFLWVI PILGWNHFMQ QTSVRREDKC
   181  ETDFYDVTWF KVMTAIINFY LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR
   241  PENPKGDAKK PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL
   301  YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ MLGDSQSFSR
   361  TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ YVSGLHMNRE RKAAKQLGFI
   421  MAAFILCWIP YFIFFMVIAF CKNCCNEHLH MFTIWLGYIN STLNPLIYPL CNENFKKTFK
   481  RILHIRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 13 nTPM
  • blood vessel: 12 nTPM
  • colon: 7.8 nTPM
  • fallopian tube: 6.9 nTPM
  • cerebral cortex: 6.6 nTPM
  • gallbladder: 6.6 nTPM

Single-cell type

  • urothelial cells: 269 nCPM
  • endometrial glandular cells: 244 nCPM
  • fallopian tube ciliated cells: 227 nCPM
  • fallopian secretory cells: 219 nCPM
  • hofbauer cells: 190 nCPM
  • endometrial secretory cells: 180 nCPM

Immune cell

  • T-reg: 0.9 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • basophil: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 10 nTPM
  • hypothalamus: 9.9 nTPM
  • amygdala: 8.7 nTPM
  • basal ganglia: 8.4 nTPM
  • hippocampal formation: 7.5 nTPM
  • medulla oblongata: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.81
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRH1 as an antibody target. Whether an autoantibody or antibody against HRH1 could matter depends on whether native HRH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRH1 is annotated at the cell surface, where native HRH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HRH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HRH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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