Seroatlas · Human Serome Atlas

HRES1

Putative HTLV-1-related endogenous sequence

Also known as: HRES1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P13985
Gene: HRES1
Canonical length: 223 aa

OverviewNCBI Gene

No narrative summary is available for HRES1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>P13985|HRES1
     1  MRCAHAPAPR TRYPTRAPSG PRPPSRSQAQ TPPRSVPRLR PRHRHPQDPR SPGPAPRHRR
    61  PPRPDPRAPP ARASYRRFRT WPSATSWERR RLSPGHRALA RGPPARLGGE GPGAGDRRRE
   121  GPDRSPRQPP VLPAAAAQPD SSSAQAPGPS TLRPAATARR KRRWATRGPA HPAFARAHGE
   181  AGAGRVRTSA RAGSTCAGWA LWRCALRWAE RQVGALGAES RFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRES1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HRES1.

Disease | ImmuneIEDB

Conditions an epitope on HRES1 was assayed in.

systemic lupus erythematosus B cell
multiple sclerosis B cell
Sjogren's syndrome B cell
human T-lymphotropic virus 1 carrier B cell
cryoglobulinemia B cell
systemic scleroderma B cell
human immunodeficiency virus infectious disease B cell
HTLV-1-associated myelopathy/tropical spastic paraparesis B cell
rheumatoid arthritis B cell

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRES1 as an antibody target. Whether an autoantibody or antibody against HRES1 could matter depends on whether native HRES1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRES1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HRES1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...