Seroatlas · Human Serome Atlas

HRCT1

Histidine-rich carboxyl terminus protein 1

Also known as: HRCT1_HUMAN, LGLL338, PRO537, UNQ338

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXD1
Gene
HRCT1
Ensembl
ENSG00000196196
Chromosome
9
Canonical length
115 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Nuclear speckles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>Q6UXD1|HRCT1
     1  MLGLLGSTAL VGWITGAAVA VLLLLLLLAT CLFHGRQDCD VERNRTAAGG NRVRRAQPWP
    61  FRRRGHLGIF HHHRHPGHVS HVPNVGLHHH HHPRHTPHHL HHHHHPHRHH PRHAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRCT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 51 nTPM
  • adipose tissue: 29 nTPM
  • breast: 24 nTPM
  • colon: 20 nTPM
  • rectum: 11 nTPM
  • small intestine: 11 nTPM

Single-cell type

  • colonocytes: 225 nCPM
  • lymphatic endothelial cells: 79 nCPM
  • goblet cells: 63 nCPM
  • enterocytes: 61 nCPM
  • vascular endothelial cells: 30 nCPM
  • cytotrophoblasts: 29 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 4.9 nTPM
  • medulla oblongata: 4.9 nTPM
  • pons: 4.8 nTPM
  • amygdala: 4.7 nTPM
  • cerebral cortex: 4.5 nTPM
  • thalamus: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.28
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Histidine-rich carboxyl terminus protein 1
  • Histidine-rich carboxyl terminus protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HRCT1 as an antibody target. Whether an autoantibody or antibody against HRCT1 could matter depends on whether native HRCT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HRCT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HRCT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HRCT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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