HRC

Protein identityUniProt · HPA

UniProt accession

P23327

Gene

HRC

Ensembl

ENSG00000130528

Chromosome

19

Canonical length

699 aa

Protein class

Predicted intracellular proteins

Subcellular location

Endoplasmic reticulum,Mitochondria,Cytosol

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>P23327|HRC
     1  MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS EEASAELRHH
    61  LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG HLLPGHRSQD HKVGDEGVSG
   121  EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH HLPSHRSHSH QDEDEDEVVS SEHHHHILRH
   181  GHRGHDGEDD EGEEEEEEEE EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH
   241  QGHEEDDDDD DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH
   301  EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD EEEDEDVSTE
   361  RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK SDEEDFQDEY KTEVPHHHHH
   421  RVPREEDEEV SAELGHQAPS HRQSHQDEET GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD
   481  DSEEEKEKEE DPGSHEEDDE SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK
   541  EEEEEEEDEE RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA
   601  SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG EHCDQCQHCQ
   661  FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HRC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

692 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.93

gnomAD pLI

0

gnomAD missense Z

-0.07

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• muscle contraction
• positive regulation of heart contraction
• positive regulation of heart rate
• positive regulation of relaxation of cardiac muscle
• regulation of calcium ion transmembrane transport
• regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
• regulation of cell communication by electrical coupling involved in cardiac conduction
• regulation of cytosolic calcium ion concentration
• regulation of heart rate
• regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Molecular functions

• ATPase binding
• calcium ion binding
• transmembrane transporter binding

Cellular components

• cytosol
• endoplasmic reticulum
• endoplasmic reticulum lumen
• mitochondrion
• sarcoplasmic reticulum lumen
• Z disc

Protein domainsUniProt · Pfam · InterPro

• Sarcoplasmic reticulum histidine-rich calcium-binding protein
• Histidine-rich calcium-binding
• Histidine-rich Calcium-binding repeat region

KeywordsUniProt

• Calcium
• Phosphoprotein
• Repeat
• Sarcoplasmic reticulum
• Signal