HOXD9

Protein identityUniProt · HPA

UniProt accession

P28356

Gene

HOXD9

Ensembl

ENSG00000128709

Chromosome

2

Canonical length

352 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>P28356|HOXD9
     1  MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA GVADGPAATA
    61  AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV PPPPLAASAS EPGRYVRSWM
   121  EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS GPANGRHYGI KPETRAAPAP ATAASTTSSS
   181  STSLSSSSKR TECSVARESQ GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS
   241  EPSACSDHPI PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL
   301  EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK GD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.68

Highest tissue expression

59 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.07

gnomAD pLI

0.02

gnomAD missense Z

0.58

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adult locomotory behavior
• anterior/posterior pattern specification
• DNA-templated transcription
• embryonic forelimb morphogenesis
• embryonic skeletal system morphogenesis
• hindlimb morphogenesis
• mammary gland development
• negative regulation of transcription by RNA polymerase II
• peripheral nervous system neuron development
• positive regulation of transcription by RNA polymerase II
• proximal/distal pattern formation
• regulation of transcription by RNA polymerase II
• single fertilization
• skeletal muscle tissue development

Molecular functions

• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleolus
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Hox9, N-terminal activation domain
• Homedomain-like superfamily
• Homeobox protein HXA9/HXB9/HXC9
• Homeobox, conserved site
• Homeodomain, metazoa
• Homeodomain
• Hox9 activation region

KeywordsUniProt

• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation