HOXD3

Protein identityUniProt · HPA

UniProt accession

P31249

Gene

HOXD3

Ensembl

ENSG00000128652

Chromosome

2

Canonical length

432 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>P31249|HOXD3
     1  MLFEQGQQAL ELPECTMQKA AYYENPGLFG GYGYSKTTDT YGYSTPHQPY PPPAAASSLD
    61  TDYPGSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG GGGGSQPPGL NSEQQPPQPP
   121  PPPPTLPPSS PTNPGGGVPA KKPKGGPNAS SSSATISKQI FPWMKESRQN SKQKNSCATA
   181  GESCEDKSPP GPASKRVRTA YTSAQLVELE KEFHFNRYLC RPRRVEMANL LNLTERQIKI
   241  WFQNRRMKYK KDQKAKGILH SPASQSPERS PPLGGAAGHV AYSGQLPPVP GLAYDAPSPP
   301  AFAKSQPNMY GLAAYTAPLS SCLPQQKRYA APEFEPHPMA SNGGGFASAN LQGSPVYVGG
   361  NFVESMAPAS GPVFNLGHLS HPSSASVDYS CAAQIPGNHH HGPCDPHPTY TDLSAHHSSQ
   421  GRLPEAPKLT HL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.69

Highest tissue expression

39 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.55

gnomAD pLI

0.44

gnomAD missense Z

1.09

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterior/posterior pattern specification
• cartilage development
• cell-matrix adhesion
• DNA-templated transcription
• embryonic skeletal system morphogenesis
• glossopharyngeal nerve morphogenesis
• Notch signaling pathway
• positive regulation of gene expression
• positive regulation of neuron differentiation
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• thyroid gland development

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• aggresome
• chromatin
• nuclear body
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homeobox protein, antennapedia type, conserved site
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain, metazoa
• Domain of unknown function DUF4074
• Homeodomain
• Domain of unknown function (DUF4074)

KeywordsUniProt

• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Transcription
• Transcription regulation