Seroatlas · Human Serome Atlas

HOXD11

Homeobox protein Hox-D11

Also known as: HOX4, HOX4F, HXD11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31277
Gene
HOXD11
Ensembl
ENSG00000128713
Chromosome
2
Canonical length
338 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>P31277|HOXD11
     1  MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE
    61  VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA
   121  EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ
   181  FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG
   241  SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS
   301  RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
6.4 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 6.4 nTPM
  • kidney: 5.1 nTPM
  • vagina: 4.3 nTPM
  • cervix: 3.4 nTPM
  • colon: 3.3 nTPM
  • prostate: 3 nTPM

Single-cell type

  • endometrial stromal cells: 32 nCPM
  • basal prostatic cells: 13 nCPM
  • decidual stromal cells: 13 nCPM
  • prostatic club cells: 7.6 nCPM
  • prostatic hillock cells: 6 nCPM
  • neuroendocrine cells: 5.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
-0.59
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXD11 as an antibody target. Whether an autoantibody or antibody against HOXD11 could matter depends on whether native HOXD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HOXD11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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