Seroatlas · Human Serome Atlas

HOXD10

Homeobox protein Hox-D10

Also known as: HOX4, HOX4D, HXD10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28358
Gene
HOXD10
Ensembl
ENSG00000128710
Chromosome
2
Canonical length
340 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as """"""""""""""""""""""""""""""""rocker-bottom foot"""""""""""""""""""""""""""""""" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>P28358|HOXD10
     1  MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT CGLLPSLAKR
    61  EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT CSFTTNIKEE SNCCMYSDKR
   121  NKLISAEVPS YQRLVPESCP VENPEVPVPG YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL
   181  NPRGAAKPQL SAAQLQMEKK MNEPVSGQEP TKVSQVESPE AKGGLPEERS CLAEVSVSSP
   241  EVQEKESKEE IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS
   301  KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 38 nTPM
  • vagina: 25 nTPM
  • kidney: 24 nTPM
  • cervix: 21 nTPM
  • colon: 18 nTPM
  • smooth muscle: 17 nTPM

Single-cell type

  • renal connecting tubule cells: 124 nCPM
  • renal collecting duct principal cells: 96 nCPM
  • distal convoluted tubule cells: 95 nCPM
  • basal prostatic cells: 78 nCPM
  • decidual stromal cells: 68 nCPM
  • loop of henle epithelial cells: 56 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 0.5 nTPM
  • amygdala: 0.2 nTPM
  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • midbrain: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HOXD10.

Disease | AllUniProt

Conditions HOXD10 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 102 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital vertical talus

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.06
gnomAD missense Z
-0.09
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXD10 as an antibody target. Whether an autoantibody or antibody against HOXD10 could matter depends on whether native HOXD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HOXD10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...