HOXC9

Protein identityUniProt · HPA

UniProt accession

P31274

Gene

HOXC9

Ensembl

ENSG00000180806

Chromosome

12

Canonical length

260 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>P31274|HOXC9
     1  MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF PSCSFAPKPA
    61  VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL SGAVSFPSFP AGGRHYALKP
   121  DAYPGRRADC GPGEGRSYPD YMYGSPGELR DRAPQTLPSP EADALAGSKH KEEKADLDPS
   181  NPVANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF
   241  QNRRMKMKKM NKEKTDKEQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.15

gnomAD pLI

0.01

gnomAD missense Z

0.35

DepMap mean gene effect

-0.22

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterior/posterior pattern specification
• DNA-templated transcription
• embryonic skeletal system morphogenesis
• negative regulation of cell cycle
• proximal/distal pattern formation
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• aggresome
• chromatin
• nucleoplasm
• nucleus
• transcription repressor complex

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Hox9, N-terminal activation domain
• Homedomain-like superfamily
• Homeobox protein HXA9/HXB9/HXC9
• Homeobox, conserved site
• Homeodomain, metazoa
• Homeodomain
• Hox9 activation region

KeywordsUniProt

• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of HOXC9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SMAD6