Seroatlas · Human Serome Atlas

HOXC12

Homeobox protein Hox-C12

Also known as: HOC3F, HOX3, HOX3F, HXC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P31275
Gene: HOXC12
Ensembl: ENSG00000123407
Chromosome: 12
Canonical length: 282 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>P31275|HOXC12
     1  MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLSWPSAEP
    61  CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA EGGGGGLKRE ERGRDPGAGP
   121  GAALLPLEPS GPPALGFKYD YAAGGGGGDG GGGAGPPHDP PSCQSLESDS SSSLLNEGNK
   181  GAGAGDPGSL VSPLNPGGGL SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT
   241  RQRRRELSDR LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 2.8 nTPM

Expression across tissuesHPA

Tissue

skin: 2.8 nTPM
blood vessel: 1.7 nTPM
adipose tissue: 1.1 nTPM
breast: 0.1 nTPM
skeletal muscle: 0.1 nTPM
adrenal gland: 0 nTPM

Single-cell type

myosatellite cells: 1.3 nCPM
basal keratinocytes: 1.1 nCPM
breast myoepithelial cells: 0.9 nCPM
neuroendocrine cells: 0.5 nCPM
early primary spermatocytes: 0.4 nCPM
suprabasal keratinocytes: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.4 nTPM
hippocampal formation: 0.5 nTPM
white matter: 0.3 nTPM
pons: 0.2 nTPM
medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.29
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXC12 as an antibody target. Whether an autoantibody or antibody against HOXC12 could matter depends on whether native HOXC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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