Seroatlas · Human Serome Atlas

HOXC11

Homeobox protein Hox-C11

Also known as: HOX3H, HXC11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43248
Gene: HOXC11
Ensembl: ENSG00000123388
Chromosome: 12
Canonical length: 304 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>O43248|HOXC11
     1  MFNSVNLGNF CSPSRKERGA DFGERGSCAS NLYLPSCTYY MPEFSTVSSF LPQAPSRQIS
    61  YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM HRECLPPSTV TEILMKNEGS
   121  YGGHHHPSAP HATPAGFYSS VNKNSVLPQA FDRFFDNAYC GGGDPPAEPP CSGKGEAKGE
   181  PEAPPASGLA SRAEAGAEAE AEEENTNPSS SGSAHSVAKE PAKGAAPNAP RTRKKRCPYS
   241  KFQIRELERE FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG
   301  NPLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

skin: 4.7 nTPM
blood vessel: 4.1 nTPM
skeletal muscle: 1.7 nTPM
adipose tissue: 1.5 nTPM
kidney: 1.1 nTPM
small intestine: 0.9 nTPM

Single-cell type

gastric progenitor cells: 9 nCPM
early primary spermatocytes: 5.2 nCPM
smooth muscle cells: 5.2 nCPM
basal keratinocytes: 4.3 nCPM
enterocytes: 3.2 nCPM
myosatellite cells: 2.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXC11 as an antibody target. Whether an autoantibody or antibody against HOXC11 could matter depends on whether native HOXC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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