Seroatlas · Human Serome Atlas

HOXB3

Homeobox protein Hox-B3

Also known as: HOX2, HOX2G, HXB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14651
Gene
HOXB3
Ensembl
ENSG00000120093
Chromosome
17
Canonical length
431 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>P14651|HOXB3
     1  MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA
    61  APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG
   121  TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK
   181  SPPGSAASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR
   241  MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN
   301  AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD
   361  PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG
   421  RIQEAPKLTH L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 67 nTPM
  • colon: 43 nTPM
  • kidney: 41 nTPM
  • fallopian tube: 35 nTPM
  • small intestine: 27 nTPM
  • seminal vesicle: 24 nTPM

Single-cell type

  • renal collecting duct principal cells: 355 nCPM
  • loop of henle epithelial cells: 245 nCPM
  • renal connecting tubule cells: 244 nCPM
  • renal collecting duct intercalated cells: 218 nCPM
  • papillary tip epithelial cells: 212 nCPM
  • distal convoluted tubule cells: 207 nCPM

Immune cell

  • plasmacytoid DC: 0.6 nTPM
  • basophil: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM

Brain region

  • medulla oblongata: 62 nTPM
  • spinal cord: 52 nTPM
  • white matter: 29 nTPM
  • pons: 28 nTPM
  • midbrain: 1.5 nTPM
  • thalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.89
gnomAD missense Z
0.12
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXB3 as an antibody target. Whether an autoantibody or antibody against HOXB3 could matter depends on whether native HOXB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HOXB3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...