HOXB2
Homeobox protein Hox-B2
Also known as: HOX2, HOX2H, HXB2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P14652
- Gene
- HOXB2
- Ensembl
- ENSG00000173917
- Chromosome
- 17
- Canonical length
- 356 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
356 residues, UniProt reviewed canonical sequence.
>P14652|HOXB2
1 MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE QTFPSLQPGA
61 STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE KKSAKKPSQS ATSPSPAASA
121 VPASGVGSPA DGLGLPEAGG GGARRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL
181 DLTERQVKVW FQNRRMKHKR QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA
241 AWEACCHPPE VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD
301 SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA IDLQFPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HOXB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 45 nTPM
Expression across tissuesHPA
Tissue
- kidney: 45 nTPM
- epididymis: 40 nTPM
- colon: 39 nTPM
- fallopian tube: 28 nTPM
- adrenal gland: 26 nTPM
- blood vessel: 24 nTPM
Single-cell type
- epididymal principal cells: 240 nCPM
- epididymal efferent duct absorptive cells: 133 nCPM
- epididymal basal cells: 89 nCPM
- epididymal efferent duct ciliated cells: 83 nCPM
- esophageal apical cells: 82 nCPM
- fallopian secretory cells: 72 nCPM
Immune cell
- naive CD4 T-cell: 6.8 nTPM
- T-reg: 6.1 nTPM
- plasmacytoid DC: 4.8 nTPM
- memory CD4 T-cell: 4.6 nTPM
- basophil: 3.9 nTPM
- memory CD8 T-cell: 3.4 nTPM
Brain region
- medulla oblongata: 32 nTPM
- spinal cord: 25 nTPM
- white matter: 22 nTPM
- pons: 19 nTPM
- midbrain: 1.3 nTPM
- cerebellum: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.33
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.57
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anterior/posterior pattern specification
- dorsal/ventral pattern formation
- embryonic skeletal system morphogenesis
- facial nerve structural organization
- morphogenesis of an epithelial sheet
- nervous system development
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- rhombomere 4 development
- neural nucleus development
- rhombomere 3 development
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HOXB2 as an antibody target. Whether an autoantibody or antibody against HOXB2 could matter depends on whether native HOXB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HOXB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HOXB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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