HOXB13

Protein identityUniProt · HPA

UniProt accession

Q92826

Gene

HOXB13

Ensembl

ENSG00000159184

Chromosome

17

Canonical length

284 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q92826|HOXB13
     1  MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP LDLPGSAEPP
    61  KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP AETPTAGEEY
   121  PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS
   181  QMCCQGEQNP PGPFWKAAFA DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF
   241  ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXB13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

77 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HOXB13.

Disease | AllUniProt

Conditions HOXB13 is implicated in, by any mechanism.

• Prostate cancer, hereditary, 9 (HPC9) MIM:610997

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 1,925 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Prostate cancer susceptibility
• Hereditary cancer-predisposing syndrome
• Prostate cancer, hereditary, 9
• Carcinoma of pancreas
• Familial prostate cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.71

gnomAD pLI

0

gnomAD missense Z

0

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• epidermis development
• epithelial cell maturation involved in prostate gland development
• negative regulation of transcription by RNA polymerase II
• prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
• regulation of growth
• regulation of transcription by RNA polymerase II
• response to testosterone
• response to wounding

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• methyl-CpG binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleoplasm
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeobox protein Hox1A3 N-terminal
• Anterior-posterior axis regulatory homeobox
• Homeodomain
• Hox protein A13 N terminal

KeywordsUniProt

• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Transcription
• Transcription regulation