Seroatlas · Human Serome Atlas

HOXA3

Homeobox protein Hox-A3

Also known as: HOX1, HOX1E, HXA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43365
Gene: HOXA3
Ensembl: ENSG00000105997
Chromosome: 7
Canonical length: 443 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>O43365|HOXA3
     1  MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC SLQSPSSAGG
    61  HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP APQPPQPAPQ PPAPTPAAPP
   121  PPSSASPPQN ASNNPTPANA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SSSSSGESCA
   181  GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ
   241  NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP
   301  PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ GNGSYGTPHI
   361  QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG AGPLGSGHHH GPGPGEPHPT
   421  YTDLTGHHPS QGRIQEAPKL THL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 18 nTPM
blood vessel: 15 nTPM
kidney: 12 nTPM
colon: 11 nTPM
endometrium: 9.6 nTPM
small intestine: 8.9 nTPM

Single-cell type

late spermatids: 92 nCPM
renal connecting tubule cells: 65 nCPM
loop of henle epithelial cells: 63 nCPM
tuft cells: 58 nCPM
hematopoietic stem cells: 44 nCPM
epididymal efferent duct absorptive cells: 42 nCPM

Immune cell

neutrophil: 1 nTPM
NK-cell: 0.5 nTPM
basophil: 0.4 nTPM
myeloid DC: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
eosinophil: 0.2 nTPM

Brain region

medulla oblongata: 22 nTPM
spinal cord: 20 nTPM
pons: 16 nTPM
white matter: 15 nTPM
midbrain: 0.9 nTPM
thalamus: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HOXA3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.94
gnomAD missense Z: 0.28
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXA3 as an antibody target. Whether an autoantibody or antibody against HOXA3 could matter depends on whether native HOXA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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