Seroatlas · Human Serome Atlas

HORMAD2

HORMA domain-containing protein 2

Also known as: CT46.2, HORM2_HUMAN, MGC26710

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7B1
Gene: HORMAD2
Ensembl: ENSG00000176635
Chromosome: 22
Canonical length: 307 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to be involved in meiotic cell cycle and meiotic sister chromatid cohesion. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q8N7B1|HORMAD2
     1  MATAQLSHCI TIHKASKETV FPSQITNEHE SLKMVKKLFA TSISCITYLR GLFPESSYGE
    61  RHLDDLSLKI LREDKKCPGS LHIIRWIQGC FDALEKRYLR MAVLTLYTDP MGSEKVTEMY
   121  QFKFKYTKEG ATMDFDSHSS STSFESGTNN EDIKKASVLL IRKLYILMQD LEPLPNNVVL
   181  TMKLHYYNAV TPHDYQPLGF KEGVNSHFLL FDKEPINVQV GFVSTGFHSM KVKVMTEATK
   241  VIDLENNLFR ENSTTEIAHQ GLDCDEEEEC NDHIQRMNFV CSQQSSECSR KKRKVSEPVK
   301  VFIPNRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HORMAD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
liver: 2.7 nTPM
basal ganglia: 0.3 nTPM
amygdala: 0.2 nTPM
midbrain: 0.2 nTPM
adipose tissue: 0.1 nTPM

Single-cell type

early primary spermatocytes: 237 nCPM
late primary spermatocytes: 176 nCPM
early spermatids: 50 nCPM
retinal pigment epithelial cells: 38 nCPM
hepatocytes: 24 nCPM
endometrial glandular cells: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.6 nTPM
medulla oblongata: 0.5 nTPM
midbrain: 0.5 nTPM
cerebellum: 0.4 nTPM
pons: 0.4 nTPM
spinal cord: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HORMAD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HORMAD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HORMAD2 as an antibody target. Whether an autoantibody or antibody against HORMAD2 could matter depends on whether native HORMAD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HORMAD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HORMAD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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