Seroatlas · Human Serome Atlas

HOMEZ

Homeobox and leucine zipper protein Homez

Also known as: HOMEZ_HUMAN, KIAA1443

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IX15
Gene: HOMEZ
Ensembl: ENSG00000290292
Chromosome: 14
Canonical length: 550 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q8IX15|HOMEZ
     1  MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE LQLVWTQAAQ
    61  TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK TWFMAQRLRC GISWSSEEIE
   121  ETRARVVYRR DQLHFKSLLS FTHHAGRPPE EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG
   181  LKVEPEEPSQ MPPLPQSHQK LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS
   241  HGIGTASWNH STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT
   301  AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL SPDMQRQRKT
   361  KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI IQWFGDTRYA LKHGQLKWFR
   421  DNAVPGAPSF QDPAIPTPPP STRSLNERAE TPPLPIPPPP PDIQPLERYW AAHQQLRETD
   481  IPQLSQASRL STQQVLDWFD SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD
   541  DDDDDVIIQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOMEZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
tongue: 14 nTPM
urinary bladder: 10 nTPM
esophagus: 9.2 nTPM
seminal vesicle: 9 nTPM
kidney: 8.8 nTPM

Single-cell type

early spermatids: 356 nCPM
late primary spermatocytes: 181 nCPM
esophageal apical cells: 118 nCPM
late spermatids: 92 nCPM
epididymal principal cells: 32 nCPM
urothelial cells: 29 nCPM

Immune cell

eosinophil: 7.5 nTPM
classical monocyte: 5.1 nTPM
myeloid DC: 4.9 nTPM
intermediate monocyte: 4.6 nTPM
T-reg: 4.2 nTPM
naive CD8 T-cell: 4 nTPM

Brain region

medulla oblongata: 15 nTPM
thalamus: 15 nTPM
white matter: 14 nTPM
basal ganglia: 14 nTPM
cerebellum: 14 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.02
gnomAD missense Z: 1.07
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HOMEZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOMEZ as an antibody target. Whether an autoantibody or antibody against HOMEZ could matter depends on whether native HOMEZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOMEZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOMEZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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