Seroatlas · Human Serome Atlas

HOATZ

Cilia- and flagella-associated protein HOATZ

Also known as: C11orf88, FLJ46266, HOATZ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PI97
Gene: HOATZ
Ensembl: ENSG00000183644
Chromosome: 11
Canonical length: 169 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in axoneme assembly; flagellated sperm motility; and spermatogenesis. Predicted to be located in cilium and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q6PI97|HOATZ
     1  METGPSEEPS GRKESQEMCP PGLLVFAGSS EQDANLAKQF WISASMYPPS ESQLVLRRDS
    61  SQRLPVARPR RSRGSENSHS SQSFHLASNK NRDIFAEALK IQESEEKVKY LQKAKTREEI
   121  LQLLRKQREE RISKELISLP YKPKAKEHKA KKVVSESDKE DQEEVKTLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOATZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 159 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 159 nTPM
fallopian tube: 81 nTPM
testis: 27 nTPM
hypothalamus: 13 nTPM
hippocampal formation: 13 nTPM
basal ganglia: 12 nTPM

Single-cell type

fallopian tube ciliated cells: 1,080 nCPM
respiratory ciliated cells: 1,028 nCPM
endometrial ciliated cells: 870 nCPM
epididymal efferent duct ciliated cells: 432 nCPM
late primary spermatocytes: 311 nCPM
ependymal cells: 179 nCPM

Immune cell

neutrophil: 0.4 nTPM
basophil: 0.3 nTPM
eosinophil: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

choroid plexus: 68 nTPM
midbrain: 26 nTPM
medulla oblongata: 23 nTPM
spinal cord: 15 nTPM
white matter: 13 nTPM
pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cilia- and flagella-associated protein HOATZ-like
Cilia- and flagella-associated protein HOATZ-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOATZ as an antibody target. Whether an autoantibody or antibody against HOATZ could matter depends on whether native HOATZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOATZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOATZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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