HMX3

Protein identityUniProt · HPA

UniProt accession

A6NHT5

Gene

HMX3

Ensembl

ENSG00000188620

Chromosome

10

Canonical length

357 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryo implantation; maternal process involved in female pregnancy; and neuromuscular process controlling balance. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>A6NHT5|HMX3
     1  MPEPGPDAAG TASAQPQPPP PPPPAPKESP FSIKNLLNGD HHRPPPKPQP PPRTLFAPAS
    61  AAAAAAAAAA AAAKGALEGA AGFALSQVGD LAFPRFEIPA QRFALPAHYL ERSPAWWYPY
   121  TLTPAGGHLP RPEASEKALL RDSSPASGTD RDSPEPLLKA DPDHKELDSK SPDEIILEES
   181  DSEESKKEGE AAPGAAGASV GAAAATPGAE DWKKGAESPE KKPACRKKKT RTVFSRSQVF
   241  QLESTFDMKR YLSSSERAGL AASLHLTETQ VKIWFQNRRN KWKRQLAAEL EAANLSHAAA
   301  QRIVRVPILY HENSAAEGAA AAAAGAPVPV SQPLLTFPHP VYYSHPVVSS VPLLRPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

4.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.92

gnomAD missense Z

0.91

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain development
• cell differentiation
• embryo implantation
• inner ear morphogenesis
• maternal process involved in female pregnancy
• neuromuscular process controlling balance
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain, metazoa
• HMX Homeobox Transcription Factors
• Homeodomain

KeywordsUniProt

• Developmental protein
• Differentiation
• DNA-binding
• Homeobox
• Neurogenesis
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation