Seroatlas · Human Serome Atlas

HMOX1

Heme oxygenase 1

Also known as: bK286B10, HMOX1_HUMAN, HO-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09601
Gene
HMOX1
Ensembl
ENSG00000100292
Chromosome
22
Canonical length
288 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>P09601|HMOX1
     1  MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA
    61  LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE
   121  VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ
   181  LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA
   241  SNKVQDSAPV ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
740 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 740 nTPM
  • adipose tissue: 145 nTPM
  • lung: 139 nTPM
  • liver: 128 nTPM
  • skeletal muscle: 121 nTPM
  • kidney: 116 nTPM

Single-cell type

  • kupffer cells: 2,742 nCPM
  • syncytiotrophoblasts: 847 nCPM
  • hofbauer cells: 718 nCPM
  • macrophages: 565 nCPM
  • esophageal apical cells: 492 nCPM
  • extravillous trophoblasts: 399 nCPM

Immune cell

  • non-classical monocyte: 331 nTPM
  • intermediate monocyte: 239 nTPM
  • classical monocyte: 99 nTPM
  • total PBMC: 71 nTPM
  • neutrophil: 47 nTPM
  • myeloid DC: 45 nTPM

Brain region

  • thalamus: 58 nTPM
  • pons: 48 nTPM
  • white matter: 48 nTPM
  • cerebral cortex: 43 nTPM
  • medulla oblongata: 40 nTPM
  • basal ganglia: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HMOX1.

Disease | AllUniProt

Conditions HMOX1 is implicated in, by any mechanism.

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 320 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.01
gnomAD missense Z
-0.52
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMOX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMOX1 as an antibody target. Whether an autoantibody or antibody against HMOX1 could matter depends on whether native HMOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMOX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HMOX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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