Seroatlas · Human Serome Atlas

HMGXB3

HMG domain-containing protein 3

Also known as: HMGX3, HMGX3_HUMAN, KIAA0194, SMF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12766
Gene: HMGXB3
Ensembl: ENSG00000113716
Chromosome: 5
Canonical length: 1292 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

1292 residues, UniProt reviewed canonical sequence.

>Q12766|HMGXB3
     1  MDASYDGTEV TVVMEEIEEA YCYTSPGPPK KKKKYKIHGE KTKKPRSAYL LYYYDIYLKV
    61  QQELPHLPQS EINKKISESW RLLSVAERSY YLEKAKLEKE GLDPNSKLSA LTAVVPDIPG
   121  FRKILPRSDY IIIPKSSLQE DRSCPQLELC VAQNQMSPKG PPLVSNTAPE TVPSHAGMAE
   181  QCLAVEALAE EVGALTQSGA VQEIATSEIL SQDVLLEDAS LEVGESHQPY QTSLVIEETL
   241  VNGSPDLPTG SLAVPHPQVG ESVSVVTVMR DSSESSSSAP ATQFIMLPLP AYSVVENPTS
   301  IKLTTTYTRR GHGTCTSPGC SFTYVTRHKP PKCPTCGNFL GGKWIPKEKP AKVKVELASG
   361  VSSKGSVVKR NQQPVTTEQN SSKENASKLT LENSEAVSQL LNVAPPREVG EESEWEEVII
   421  SDAHVLVKEA PGNCGTAVTK TPVVKSGVQP EVTLGTTDND SPGADVPTPS EGTSTSSPLP
   481  APKKPTGADL LTPGSRAPEL KGRARGKPSL LAAARPMRAI LPAPVNVGRG SSMGLPRARQ
   541  AFSLSDKTPS VRTCGLKPST LKQLGQPIQQ PSGPGEVKLP SGPSNRTSQV KVVEVKPDMF
   601  PPYKYSCTVT LDLGLATSRG RGKCKNPSCS YVYTNRHKPR ICPSCGVNLA KDRTEKTTKA
   661  IEVSSPLPDV LNATEPLSTA QREIQRQSTL QLLRKVLQIP ENESELAEVF ALIHELNSSR
   721  LILSNVSEET VTIEQTSWSN YYESPSTQCL LCSSPLFKGG QNSLAGPQEC WLLTASRLQT
   781  VTAQVKMCLN PHCLALHSFI DIYTGLFNVG NKLLVSLDLL FAIRNQIKLG EDPRVSINVV
   841  LKSVQEQTEK TLTSEELSQL QELLCNGYWA FECLTVRDYN DMICGICGVA PKVEMAQRSE
   901  ENVLALKSVE FTWPEFLGSN EVNVEDFWAT METEVIEQVA FPASIPITKF DASVIAPFFP
   961  PLMRGAVVVN TEKDKNLDVQ PVPGSGSALV RLLQEGTCKL DEIGSYSEEK LQHLLRQCGI
  1021  PFGAEDSKDQ LCFSLLALYE SVQNGARAIR PPRHFTGGKI YKVCPHQVVC GSKYLVRGES
  1081  ARDHVDLLAS SRHWPPVYVV DMATSVALCA DLCYPELTNQ MWGRNQGCFS SPTEPPVSVS
  1141  CPELLDQHYT VDMTETEHSI QHPVTKTATR RIVHAGLQPN PGDPSAGHHS LALCPELAPY
  1201  ATILASIVDS KPNGVRQRPI AFDNATHYYL YNRLMDFLTS REIVNRQIHD IVQSCQPGEV
  1261  VIRDTLYRLG VAQIKTETEE EGEEEEVAAV AE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMGXB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 110 nTPM
prostate: 20 nTPM
bone marrow: 19 nTPM
breast: 18 nTPM
adrenal gland: 17 nTPM
pituitary gland: 17 nTPM

Single-cell type

cardiomyocytes: 106 nCPM
endometrial ciliated cells: 79 nCPM
pituicytes/fscs: 78 nCPM
endometrial glandular cells: 71 nCPM
respiratory ciliated cells: 69 nCPM
fallopian tube ciliated cells: 69 nCPM

Immune cell

T-reg: 4.4 nTPM
basophil: 3.5 nTPM
gdT-cell: 3.3 nTPM
myeloid DC: 3.2 nTPM
intermediate monocyte: 3.1 nTPM
memory B-cell: 3 nTPM

Brain region

choroid plexus: 29 nTPM
thalamus: 27 nTPM
cerebral cortex: 24 nTPM
white matter: 24 nTPM
midbrain: 24 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 3.51
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

High mobility group box domain
High mobility group box domain superfamily
HMG-box domain
HMG domain-containing protein 3
HMG domain-containing protein 3, CxC4 like cysteine cluster
CxC4 like cysteine cluster associated with KDZ transposases

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMGXB3 as an antibody target. Whether an autoantibody or antibody against HMGXB3 could matter depends on whether native HMGXB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMGXB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMGXB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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