HMGN3
High mobility group nucleosome-binding domain-containing protein 3
Also known as: HMGN3_HUMAN, TRIP7
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15651
- Gene
- HMGN3
- Ensembl
- ENSG00000118418
- Chromosome
- 6
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q15651|HMGN3
1 MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPAPPKPE PKPRKTSAKK EPGAKISRGA
61 KGKKEEKQEA GKEGTAPSEN GETKAEEAQK TESVDNEGELocalizationUniProt · AlphaFold · HPA
Whether an antibody against HMGN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 224 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 224 nTPM
- fallopian tube: 196 nTPM
- adrenal gland: 164 nTPM
- kidney: 160 nTPM
- choroid plexus: 158 nTPM
- retina: 155 nTPM
Single-cell type
- fallopian tube ciliated cells: 1,219 nCPM
- extravillous trophoblasts: 1,179 nCPM
- cytotrophoblasts: 1,177 nCPM
- respiratory ciliated cells: 1,039 nCPM
- migrating cytotrophoblasts: 882 nCPM
- breast lactating cells: 855 nCPM
Immune cell
- plasmacytoid DC: 213 nTPM
- myeloid DC: 182 nTPM
- total PBMC: 172 nTPM
- classical monocyte: 151 nTPM
- intermediate monocyte: 151 nTPM
- non-classical monocyte: 147 nTPM
Brain region
- choroid plexus: 108 nTPM
- cerebral cortex: 95 nTPM
- white matter: 88 nTPM
- cerebellum: 81 nTPM
- medulla oblongata: 79 nTPM
- spinal cord: 71 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.03
- gnomAD pLI
- 0.06
- gnomAD missense Z
- 0.76
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HMGN3 as an antibody target. Whether an autoantibody or antibody against HMGN3 could matter depends on whether native HMGN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HMGN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HMGN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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