Seroatlas · Human Serome Atlas

HMGN2P46

Putative Dresden prostate carcinoma protein 2

Also known as: DPCA2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SG4
Gene: HMGN2P46
Canonical length: 172 aa

OverviewNCBI Gene

No narrative summary is available for HMGN2P46 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q86SG4|HMGN2P46
     1  MEPWAMRALD FADESGSVSC KDMHLLLWLQ KRIEMHKAEQ CEEEEAMTPR PTKARAPLPS
    61  AYVPPLSLPP CPRERLKGML KEIKPRLSRN CREDPQGCLL NLLLQSHSRS PERPLQRRER
   121  RYLQRRREKL MLARRGITLQ KMEMPKQTRH RKLKVLEMPS EVCAFLITVY FW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMGN2P46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMGN2P46 as an antibody target. Whether an autoantibody or antibody against HMGN2P46 could matter depends on whether native HMGN2P46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMGN2P46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMGN2P46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...