Seroatlas · Human Serome Atlas

HMGCLL1

3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

Also known as: bA418P12.1, DKFZP434G1411, HMGC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB92
Gene: HMGCLL1
Ensembl: ENSG00000146151
Chromosome: 6
Canonical length: 370 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables hydroxymethylglutaryl-CoA lyase activity. Involved in ketone body biosynthetic process. Located in several cellular components, including cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q8TB92|HMGCLL1
     1  MGNVPSAVKH CLSYQQLLRE HLWIGDSVAG ALDPAQTSLL TNLHCFQPDV SGFSVSLAGT
    61  VACIHWETSQ LSGLPEFVKI VEVGPRDGLQ NEKVIVPTDI KIEFINRLSQ TGLSVIEVTS
   121  FVSSRWVPQM ADHTEVMKGI HQYPGVRYPV LTPNLQGFHH AVAAGATEIS VFGAASESFS
   181  KKNINCSIEE SMGKFEEVVK SARHMNIPAR GYVSCALGCP YEGSITPQKV TEVSKRLYGM
   241  GCYEISLGDT IGVGTPGSMK RMLESVMKEI PPGALAVHCH DTYGQALANI LTALQMGINV
   301  VDSAVSGLGG CPYAKGASGN VATEDLIYML NGLGLNTGVN LYKVMEAGDF ICKAVNKTTN
   361  SKVAQASFNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMGCLL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 9.1 nTPM
cerebral cortex: 8.4 nTPM
basal ganglia: 8.1 nTPM
spinal cord: 7.8 nTPM
midbrain: 6.6 nTPM
cerebellum: 6 nTPM

Single-cell type

pituitary stem cells: 362 nCPM
thyrotrophs: 182 nCPM
pancreatic islet cells: 180 nCPM
lactotrophs: 173 nCPM
bergmann glia: 169 nCPM
fibro-adipogenic progenitors: 148 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 32 nTPM
white matter: 29 nTPM
spinal cord: 29 nTPM
thalamus: 28 nTPM
midbrain: 23 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: -0.49
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMGCLL1 as an antibody target. Whether an autoantibody or antibody against HMGCLL1 could matter depends on whether native HMGCLL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMGCLL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMGCLL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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