HMGB1P1
High mobility group protein B1-like 1
Also known as: HGB1A_HUMAN, HMG1L1, HMG1L7, HMGB1L1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B2RPK0
- Gene
- HMGB1P1
- Ensembl
- ENSG00000124097
- Chromosome
- 20
- Canonical length
- 211 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene may represent an evolving retropseudogene of the high-mobility group box 1 gene, which has multiple pseudogenes. This gene has an intact open reading frame, where the length of encoded protein is conserved, compared to the high-mobility group box 1 protein. However, due to the lack of conclusive evidence for specific transcription at this location, this locus is currently represented as a pseudogene. [provided by RefSeq, Jan 2010]
Canonical amino-acid sequenceUniProt
211 residues, UniProt reviewed canonical sequence.
>B2RPK0|HMGB1P1
1 MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HSDASVNFSE FSNKCSERWK TMSAKEKGKF
61 EDMAKADKTH YERQMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYH PKIKGEHPGL
121 SIGDVAKKLG EMWNNTAADD KQPGEKKAAK LKEKYEKDIA AYQAKGKPEA AKKGVVKAEK
181 SKKKKEEEED EEDEEDEEEE DEEDEEDDDD ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against HMGB1P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 1.1 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 1.1 nTPM
- spleen: 0.7 nTPM
- bone marrow: 0.5 nTPM
- epididymis: 0.5 nTPM
- fallopian tube: 0.5 nTPM
- lymph node: 0.5 nTPM
Single-cell type
- tuft cells: 127 nCPM
- megakaryocytes: 62 nCPM
- epididymal efferent duct ciliated cells: 12 nCPM
- megakaryocyte progenitors: 7.7 nCPM
- erythrocyte progenitors: 5.7 nCPM
- mast cells: 4.9 nCPM
Immune cell
- basophil: 2.4 nTPM
- eosinophil: 2.2 nTPM
- total PBMC: 2 nTPM
- T-reg: 1.8 nTPM
- NK-cell: 1.6 nTPM
- naive B-cell: 1.5 nTPM
Brain region
- choroid plexus: 2.1 nTPM
- midbrain: 1.7 nTPM
- cerebellum: 1.6 nTPM
- medulla oblongata: 1.6 nTPM
- hippocampal formation: 1.5 nTPM
- basal ganglia: 1.3 nTPM
OntologyGO
Biological processes
- cell development
- chromatin remodeling
- DNA metabolic process
- immune response
- negative regulation of endothelial cell migration
- positive regulation of autophagy
- positive regulation of cell differentiation
- positive regulation of chemokine production
- positive regulation of endothelial cell proliferation
- positive regulation of interleukin-1 production
- positive regulation of interleukin-6 production
- positive regulation of tumor necrosis factor production
- regulation of hemopoiesis
- regulation of viral process
- regulation of DNA metabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HMGB1P1 as an antibody target. Whether an autoantibody or antibody against HMGB1P1 could matter depends on whether native HMGB1P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HMGB1P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HMGB1P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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