Seroatlas · Human Serome Atlas

HMCES

Abasic site processing protein HMCES

Also known as: C3orf37, DC12, HMCES_HUMAN, SRAPD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FZ2
Gene: HMCES
Ensembl: ENSG00000183624
Chromosome: 3
Canonical length: 354 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables DNA-(abasic site) binding activity; protein-DNA covalent cross-linking activity; and single-stranded DNA binding activity. Involved in interstrand cross-link repair; protein-DNA covalent cross-linking repair; and somatic hypermutation of immunoglobulin genes. Is active in replication fork. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q96FZ2|HMCES
     1  MCGRTSCHLP RDVLTRACAY QDRRGQQRLP EWRDPDKYCP SYNKSPQSNS PVLLSRLHFE
    61  KDADSSERII APMRWGLVPS WFKESDPSKL QFNTTNCRSD TVMEKRSFKV PLGKGRRCVV
   121  LADGFYEWQR CQGTNQRQPY FIYFPQIKTE KSGSIGAADS PENWEKVWDN WRLLTMAGIF
   181  DCWEPPEGGD VLYSYTIITV DSCKGLSDIH HRMPAILDGE EAVSKWLDFG EVSTQEALKL
   241  IHPTENITFH AVSSVVNNSR NNTPECLAPV DLVVKKELRA SGSSQRMLQW LATKSPKKED
   301  SKTPQKEESD VPQWSSQFLQ KSPLPTKRGT AGLLEQWLKR EKEEEPVAKR PYSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMCES can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

tonsil: 123 nTPM
lymph node: 93 nTPM
parathyroid gland: 65 nTPM
skeletal muscle: 54 nTPM
thymus: 53 nTPM
liver: 50 nTPM

Single-cell type

plasma cells: 226 nCPM
early primary spermatocytes: 179 nCPM
epididymal basal cells: 134 nCPM
oocytes: 129 nCPM
tuft cells: 127 nCPM
esophageal basal cells: 92 nCPM

Immune cell

eosinophil: 65 nTPM
naive B-cell: 62 nTPM
neutrophil: 53 nTPM
T-reg: 48 nTPM
non-classical monocyte: 41 nTPM
naive CD8 T-cell: 40 nTPM

Brain region

hypothalamus: 44 nTPM
cerebral cortex: 44 nTPM
basal ganglia: 44 nTPM
pons: 34 nTPM
midbrain: 34 nTPM
medulla oblongata: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA-(abasic site) binding
peptidase activity
single-stranded DNA binding
protein-DNA covalent cross-linking activity

Cellular components

replication fork

Protein domainsUniProt · Pfam · InterPro

SOS response associated peptidase (SRAP)
SOS response associated peptidase-like
SOS response associated peptidase (SRAP)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HMCES in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PCNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMCES as an antibody target. Whether an autoantibody or antibody against HMCES could matter depends on whether native HMCES is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMCES is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HMCES as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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