Seroatlas · Human Serome Atlas

HLX

H2.0-like homeobox protein

Also known as: HB24, HLX_HUMAN, HLX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14774
Gene: HLX
Ensembl: ENSG00000136630
Chromosome: 1
Canonical length: 488 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables sequence-specific DNA binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q14774|HLX
     1  MFAAGLAPFY ASNFSLWSAA YCSSAGPGGC SFPLDPAAVK KPSFCIADIL HAGVGDLGAA
    61  PEGLAGASAA ALTAHLGSVH PHASFQAAAR SPLRPTPVVA PSEVPAGFPQ RLSPLSAAYH
   121  HHHPQQQQQQ QQPQQQQPPP PPRAGALQPP ASGTRVVPNP HHSGSAPAPS SKDLKFGIDR
   181  ILSAEFDPKV KEGNTLRDLT SLLTGGRPAG VHLSGLQPSA GQFFASLDPI NEASAILSPL
   241  NSNPRNSVQH QFQDTFPGPY AVLTKDTMPQ TYKRKRSWSR AVFSNLQRKG LEKRFEIQKY
   301  VTKPDRKQLA AMLGLTDAQV KVWFQNRRMK WRHSKEAQAQ KDKDKEAGEK PSGGAPAADG
   361  EQDERSPSRS EGEAESESSD SESLDMAPSD TERTEGSERS LHQTTVIKAP VTGALITASS
   421  AGSGGSSGGG GNSFSFSSAS SLSSSSTSAG CASSLGGGGA SELLPATQPT ASSAPKSPEP
   481  AQGALGCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HLX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 86 nTPM
colon: 40 nTPM
adipose tissue: 28 nTPM
lung: 21 nTPM
liver: 19 nTPM
heart muscle: 18 nTPM

Single-cell type

neutrophils: 69 nCPM
hofbauer cells: 63 nCPM
neutrophil progenitors: 49 nCPM
monocytes: 31 nCPM
vascular endothelial cells: 29 nCPM
hepatic stellate cells: 26 nCPM

Immune cell

basophil: 67 nTPM
neutrophil: 58 nTPM
eosinophil: 23 nTPM
myeloid DC: 13 nTPM
classical monocyte: 11 nTPM
plasmacytoid DC: 8.8 nTPM

Brain region

thalamus: 4.3 nTPM
hippocampal formation: 3 nTPM
medulla oblongata: 2.9 nTPM
pons: 2.8 nTPM
spinal cord: 2.7 nTPM
white matter: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.88
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HLX as an antibody target. Whether an autoantibody or antibody against HLX could matter depends on whether native HLX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HLX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HLX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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