HINFP
Histone H4 transcription factor
Also known as: DKFZP434F162, HiNF-P, HINFP_HUMAN, MIZF, ZNF743
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BQA5
- Gene
- HINFP
- Ensembl
- ENSG00000172273
- Chromosome
- 11
- Canonical length
- 517 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]
Canonical amino-acid sequenceUniProt
517 residues, UniProt reviewed canonical sequence.
>Q9BQA5|HINFP
1 MPPPGKVPRK ENLWLQCEWG SCSFVCSTME KFFEHVTQHL QQHLHGSGEE EEEEEEDDPL
61 EEEFSCLWQE CGFCSLDSSA DLIRHVYFHC YHTKLKQWGL QALQSQADLG PCILDFQSRN
121 VIPDIPDHFL CLWEHCENSF DNPEWFYRHV EAHSLCCEYE AVGKDNPVVL CGWKGCTCTF
181 KDRSKLREHL RSHTQEKVVA CPTCGGMFAN NTKFLDHIRR QTSLDQQHFQ CSHCSKRFAT
241 ERLLRDHMRN HVNHYKCPLC DMTCPLPSSL RNHMRFRHSE DRPFKCDCCD YSCKNLIDLQ
301 KHLDTHSEEP AYRCDFENCT FSARSLCSIK SHYRKVHEGD SEPRYKCHVC DKCFTRGNNL
361 TVHLRKKHQF KWPSGHPRFR YKEHEDGYMR LQLVRYESVE LTQQLLRQPQ EGSGLGTSLN
421 ESSLQGIILE TVPGEPGRKE EEEEGKGSEG TALSASQDNP SSVIHVVNQT NAQGQQEIVY
481 YVLSEAPGEP PPAPEPPSGG IMEKLQGIAE EPEIQMVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HINFP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 17 nTPM
- thymus: 11 nTPM
- retina: 10 nTPM
- skeletal muscle: 8.7 nTPM
- basal ganglia: 8.3 nTPM
- skin: 8.2 nTPM
Single-cell type
- early primary spermatocytes: 69 nCPM
- rod photoreceptor cells: 39 nCPM
- cone photoreceptor cells: 37 nCPM
- differentiating spermatogonia: 36 nCPM
- tuft cells: 35 nCPM
- colonocytes: 28 nCPM
Immune cell
- NK-cell: 17 nTPM
- T-reg: 17 nTPM
- myeloid DC: 17 nTPM
- naive CD4 T-cell: 16 nTPM
- classical monocyte: 13 nTPM
- basophil: 13 nTPM
Brain region
- cerebellum: 26 nTPM
- white matter: 25 nTPM
- cerebral cortex: 22 nTPM
- basal ganglia: 21 nTPM
- thalamus: 21 nTPM
- medulla oblongata: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.51
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.68
- DepMap mean gene effect
- -1.6
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell cycle G1/S phase transition
- DNA damage checkpoint signaling
- DNA repair
- DNA-templated transcription
- establishment of protein localization
- G1/S transition of mitotic cell cycle
- in utero embryonic development
- myoblast differentiation
- negative regulation of DNA-templated transcription
- negative regulation of gene expression
- positive regulation of DNA-templated transcription
- positive regulation of gene expression
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
Molecular functions
- chromatin binding
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- enzyme binding
- histone binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- transcription cis-regulatory region binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HINFP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HINFP as an antibody target. Whether an autoantibody or antibody against HINFP could matter depends on whether native HINFP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HINFP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HINFP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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