Seroatlas · Human Serome Atlas

HILPDA

Hypoxia-inducible lipid droplet-associated protein

Also known as: C7orf68, FLJ21076, HIG-2, HIG2, HLPDA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5L2
Gene: HILPDA
Ensembl: ENSG00000135245
Chromosome: 7
Canonical length: 63 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Lipid droplets
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables signaling receptor binding activity. Involved in several processes, including autocrine signaling; cellular response to hypoxia; and positive regulation of lipid storage. Located in several cellular components, including cell surface; lipid droplet; and secretory granule. Implicated in colorectal cancer and hepatocellular carcinoma. Biomarker of colorectal cancer and hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

63 residues, UniProt reviewed canonical sequence.

>Q9Y5L2|HILPDA
     1  MKHVLNLYLL GVVLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS
    61  RSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HILPDA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 159 nTPM

Expression across tissuesHPA

Tissue

esophagus: 159 nTPM
adipose tissue: 93 nTPM
vagina: 88 nTPM
cervix: 74 nTPM
blood vessel: 66 nTPM
choroid plexus: 60 nTPM

Single-cell type

astrocytes: 30 nCPM
papillary tip epithelial cells: 11 nCPM
bergmann glia: 8.7 nCPM
podocytes: 8.3 nCPM
esophageal apical cells: 6.2 nCPM
ependymal cells: 4.7 nCPM

Immune cell

eosinophil: 68 nTPM
basophil: 21 nTPM
memory B-cell: 18 nTPM
naive B-cell: 18 nTPM
NK-cell: 14 nTPM
plasmacytoid DC: 12 nTPM

Brain region

medulla oblongata: 45 nTPM
midbrain: 44 nTPM
thalamus: 42 nTPM
cerebellum: 36 nTPM
spinal cord: 34 nTPM
pons: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.32
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Hypoxia-inducible lipid droplet-associated protein
Hypoxia-inducible lipid droplet-associated

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HILPDA as an antibody target. Whether an autoantibody or antibody against HILPDA could matter depends on whether native HILPDA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HILPDA is annotated as secreted, so native HILPDA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HILPDA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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