Seroatlas · Human Serome Atlas

HIDE1

Protein HIDE1

Also known as: C19orf38, HIDE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MVS5
Gene: HIDE1
Ensembl: ENSG00000214212
Chromosome: 19
Canonical length: 230 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>A8MVS5|HIDE1
     1  MPWTILLFAA GSLAIPAPSI RLVPPYPSSQ EDPIHIACMA PGNFPGANFT LYRGGQVVQL
    61  LQAPTDQRGV TFNLSGGSSK APGGPFHCQY GVLGELNQSQ LSDLSEPVNV SFPVPTWILV
   121  LSLSLAGALF LLAGLVAVAL VVRKVKLRNL QKKRDRESCW AQINFDSTDM SFDNSLFTVS
   181  AKTMPEEDPA TLDDHSGTTA TPSNSRTRKR PTSTSSSPET PEFSTFRACQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HIDE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 93 nTPM
spleen: 21 nTPM
testis: 11 nTPM
appendix: 11 nTPM
lung: 6 nTPM
choroid plexus: 5.4 nTPM

Single-cell type

neutrophils: 122 nCPM
monocytes: 104 nCPM
neutrophil progenitors: 76 nCPM
monocyte progenitors: 45 nCPM
early primary spermatocytes: 38 nCPM
cdc: 36 nCPM

Immune cell

non-classical monocyte: 394 nTPM
intermediate monocyte: 313 nTPM
classical monocyte: 283 nTPM
neutrophil: 231 nTPM
eosinophil: 170 nTPM
myeloid DC: 162 nTPM

Brain region

white matter: 7.3 nTPM
medulla oblongata: 6.5 nTPM
pons: 5.3 nTPM
spinal cord: 5 nTPM
cerebellum: 4.4 nTPM
hypothalamus: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.01
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin-like fold
Immunoglobulin-like domain superfamily
Protein HIDE1
C19orf38, Ig domain
Ig domain in C19orf38 (HIDE1)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HIDE1 as an antibody target. Whether an autoantibody or antibody against HIDE1 could matter depends on whether native HIDE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HIDE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HIDE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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