Seroatlas · Human Serome Atlas

HHATL

Protein-cysteine N-palmitoyltransferase HHAT-like protein

Also known as: C3orf3, GUP1, HHATL_HUMAN, KIAA1173, MBOAT3, MSTP002, OACT3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCP6
Gene: HHATL
Ensembl: ENSG00000010282
Chromosome: 3
Canonical length: 504 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in negative regulation of N-terminal protein palmitoylation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q9HCP6|HHATL
     1  MGIKTALPAA ELGLYSLVLS GALAYAGRGL LEASQDGAHR KAFRESVRPG WEYIGRKMDV
    61  ADFEWVMWFT SFRNVIIFAL SGHVLFAKLC TMVAPKLRSW MYAVYGALAV MGTMGPWYLL
   121  LLLGHCVGLY VASLLGQPWL CLGLGLASLA SFKMDPLISW QSGFVTGTFD LQEVLFHGGS
   181  SFTVLRCTSF ALESCAHPDR HYSLADLLKY NFYLPFFFFG PIMTFDRFHA QVSQVEPVRR
   241  EGELWHIRAQ AGLSVVAIMA VDIFFHFFYI LTIPSDLKFA NRLPDSALAG LAYSNLVYDW
   301  VKAAVLFGVV NTVACLDHLD PPQPPKCITA LYVFAETHFD RGINDWLCKY VYNHIGGEHS
   361  AVIPELAATV ATFAITTLWL GPCDIVYLWS FLNCFGLNFE LWMQKLAEWG PLARIEASLS
   421  VQMSRRVRAL FGAMNFWAII MYNLVSLNSL KFTELVARRL LLTGFPQTTL SILFVTYCGV
   481  QLVKERERTL ALEEEQKQDK EKPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HHATL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 488 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 488 nTPM
skeletal muscle: 265 nTPM
spinal cord: 233 nTPM
tongue: 144 nTPM
midbrain: 97 nTPM
basal ganglia: 70 nTPM

Single-cell type

oligodendrocytes: 73 nCPM
retinal bipolar cells: 70 nCPM
astrocytes: 60 nCPM
müller glia: 41 nCPM
thymic myoid cells: 39 nCPM
melanocytes: 33 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 434 nTPM
basal ganglia: 286 nTPM
medulla oblongata: 268 nTPM
midbrain: 264 nTPM
pons: 215 nTPM
thalamus: 213 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of N-terminal protein palmitoylation
regulation of protein modification process

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HHATL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HHATL as an antibody target. Whether an autoantibody or antibody against HHATL could matter depends on whether native HHATL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HHATL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HHATL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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