Seroatlas · Human Serome Atlas

HERC2P3

Putative HERC2-like protein 3

Also known as: HRC23_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVR0
Gene: HERC2P3
Canonical length: 1158 aa

OverviewNCBI Gene

No narrative summary is available for HERC2P3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1158 residues, UniProt reviewed canonical sequence.

>Q9BVR0|HERC2P3
     1  MHAFCVGQYL EPDQEGVTIP DLGSLSSPLI DTERNLGLLL GLHASYLAMS TPLSPVEIEC
    61  AKWLQSSIFS GGLQTSQIHY SYNEEKDEDH CSSPGGTPAS KSRLCSHRRA LGDHSQAFLQ
   121  AIADNNIQDH NVKDFLCQIE RYCRQCHLTT PIMFPPEHPV EEVGRLLLCC LLKHEDLGHV
   181  ALSLVHAGAL GIEQVKHRTL PKSVVDVCRV VYQAKCSLIK THQEQGRSYK EVCAPVIERL
   241  RFLFNELRPA VCNDLSIMSK FKLLSSLPHW RRIAQKIIRE PRKKRVPKKP ESTDDEEKIG
   301  NEESDLEEAC ILPHSPINVD KRPIAIKSPK DKWQPLLSTV TGVHKYKWLK QNVQGLYPQS
   361  PLLSTIAEFA LKEEPVDVEK RKCLLKQLER AEVRLEGIDT ILKLYLVSKN FLLPSVPYAM
   421  FCGWQRLIPE GIDIGEPLTD CLKDVDLIPP FNRMLLEVTF GKLYAWAVQN IRNVLVDASA
   481  KFKELGIQPV PLQTITNENP SGPSLGTIPQ AHFLLVMLSM LTLQHSANNL DLLLNSGTLA
   541  LAQTALRLIG PSCDSVEEDM NASAQGASAT VLEETRKETA PVQLPVSGPE LAAMMKIGTR
   601  VMRGVDWKWG DQDRPPPGLG RVIGELGEDG WIRVQWDTGS TNSYRMGKEG NYDLKLAELP
   661  APAQPSAEDS DTEDDSEAEQ TERNIHPTAM MFTSTINLLQ TLCLSAGVHA EIMQSEATKT
   721  LCGLLQMLVY REQHRSWCTL GFVQSIALTL QVCGTLSSLQ WITLLMKVVE GHAPFTATSL
   781  QRQILAVHLL QAVLPSWDKT ERARDMKCLM EKLFDFLGSL LTMCSSDVPL LRESTLRRRR
   841  VCPQASLTAT HSSTLAEEVV ALLHTLHSLT QWNGLINKYI NSQLRSITHS FAGRPSKGAQ
   901  LEDYFPDSEN PEVGGLMAVL AVVGGIDGRL CLGGQVVHDD FGEVTMTRIT LKGKITVQFS
   961  DMRTCHVCPL NQLKPLPAVA FNVNNLPFTE PMLSVWAQLV NLAGSKLEKH KIKKSTKQAF
  1021  AGQVDLDLLR CQQLKLYILK AGRALFSHQD KLRQILSQPA VQETGTVHTD DGAVVSPDLG
  1081  DMSPEGPQPP MILLQQLLAS ATQPSPVKAI FDKQELEERM SRCCFWRRRT TKLEQILLFI
  1141  RRMNSVCEKE NTNATASN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HERC2P3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HERC2P3 as an antibody target. Whether an autoantibody or antibody against HERC2P3 could matter depends on whether native HERC2P3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HERC2P3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HERC2P3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...