Seroatlas · Human Serome Atlas

HEPACAM2

HEPACAM family member 2

Also known as: FLJ38683, HECA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MVW5
Gene
HEPACAM2
Ensembl
ENSG00000188175
Chromosome
7
Canonical length
462 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles,Mitotic spindle

OverviewNCBI Gene

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>A8MVW5|HEPACAM2
     1  MGQDAFMEPF GDTLGVFQCK IYLLLFGACS GLKVTVPSHT VHGVRGQALY LPVHYGFHTP
    61  ASDIQIIWLF ERPHTMPKYL LGSVNKSVVP DLEYQHKFTM MPPNASLLIN PLQFPDEGNY
   121  IVKVNIQGNG TLSASQKIQV TVDDPVTKPV VQIHPPSGAV EYVGNMTLTC HVEGGTRLAY
   181  QWLKNGRPVH TSSTYSFSPQ NNTLHIAPVT KEDIGNYSCL VRNPVSEMES DIIMPIIYYG
   241  PYGLQVNSDK GLKVGEVFTV DLGEAILFDC SADSHPPNTY SWIRRTDNTT YIIKHGPRLE
   301  VASEKVAQKT MDYVCCAYNN ITGRQDETHF TVIITSVGLE KLAQKGKSLS PLASITGISL
   361  FLIISMCLLF LWKKYQPYKV IKQKLEGRPE TEYRKAQTFS GHEDALDDFG IYEFVAFPDV
   421  SGVSRIPSRS VPASDCVSGQ DLHSTVYEVI QHIPAQQQDH PE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEPACAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
90 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 90 nTPM
  • colon: 60 nTPM
  • small intestine: 45 nTPM
  • duodenum: 28 nTPM
  • kidney: 14 nTPM
  • stomach: 9.6 nTPM

Single-cell type

  • goblet cells: 619 nCPM
  • respiratory ionocytes: 340 nCPM
  • epididymal clear cells: 339 nCPM
  • tuft cells: 334 nCPM
  • neuroendocrine cells: 233 nCPM
  • salivary ionocytes: 212 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 0.4 nTPM
  • medulla oblongata: 0.3 nTPM
  • midbrain: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.25
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEPACAM2 as an antibody target. Whether an autoantibody or antibody against HEPACAM2 could matter depends on whether native HEPACAM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEPACAM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEPACAM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HEPACAM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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