Seroatlas · Human Serome Atlas

HEBP1

Heme-binding protein 1

Also known as: HBP, HEBP, HEBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRV9
Gene: HEBP1
Ensembl: ENSG00000013583
Chromosome: 12
Canonical length: 189 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q9NRV9|HEBP1
     1  MLGMIKNSLF GSVETWPWQV LSKGDKEEVA YEERACEGGK FATVEVTDKP VDEALREAMP
    61  KVAKYAGGTN DKGIGMGMTV PISFAVFPNE DGSLQKKLKV WFRIPNQFQS DPPAPSDKSV
   121  KIEEREGITV YSMQFGGYAK EADYVAQATR LRAALEGTAT YRGDIYFCTG YDPPMKPYGR
   181  RNEIWLLKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 228 nTPM

Expression across tissuesHPA

Tissue

duodenum: 228 nTPM
small intestine: 156 nTPM
liver: 136 nTPM
thyroid gland: 115 nTPM
adrenal gland: 105 nTPM
ovary: 85 nTPM

Single-cell type

enterocytes: 748 nCPM
erythrocyte progenitors: 269 nCPM
esophageal apical cells: 210 nCPM
breast lactating cells: 187 nCPM
lymphatic endothelial cells: 147 nCPM
hepatocytes: 147 nCPM

Immune cell

non-classical monocyte: 70 nTPM
classical monocyte: 66 nTPM
myeloid DC: 51 nTPM
intermediate monocyte: 50 nTPM
total PBMC: 26 nTPM
plasmacytoid DC: 25 nTPM

Brain region

white matter: 55 nTPM
medulla oblongata: 54 nTPM
spinal cord: 48 nTPM
basal ganglia: 47 nTPM
cerebellum: 44 nTPM
choroid plexus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: 0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

circadian rhythm

Molecular functions

heme binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEBP1 as an antibody target. Whether an autoantibody or antibody against HEBP1 could matter depends on whether native HEBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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