Seroatlas · Human Serome Atlas

HEATR9

Protein HEATR9

Also known as: C17orf66, FLJ32830, HEAT9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2RTY3
Gene: HEATR9
Ensembl: ENSG00000270379
Chromosome: 17
Canonical length: 570 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to act upstream of or within hematopoietic progenitor cell differentiation; response to cytokine; and response to virus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>A2RTY3|HEATR9
     1  MAYEKSTDIS DVSRSMFLYP WLEYPDKTKE LRKAMAPVHL PLSCYQMPKE EFPPSPECWR
    61  QHPSKPNSVP YCYFKKPEIY THWHDLYDQR EEREAEKMLR KMRDDCRYIK EVHQTHIKMF
   121  HLPMSKLTIK SEMRSRPLEP TQDPLKWQRL RELTKSLESP REDEQFYAAQ ALGCLRISDK
   181  FVMEALQQVA QTGPEKVKYE AYRTLAILGC LNKHVIRALI KQLKEKNEGQ RMETLTGLRM
   241  ALNSWAAVSK DKRTQVGDEG KLVPVLQTLI KKSSSEASLE AALCLGFLRP CSNMVQEFLL
   301  QCLCQGLKTQ RMKALRMLVK VMHVHSAPVI KAILDQLCSS SVLEDRFEAT QMLKTIGLEQ
   361  IQAQGLEELT FNLLRRKTHN EPFLAVRQAV AQTVEELKLK PTMMNLVEAQ LMNPDATARQ
   421  EAVISLGVLG IRSPQVFHLL LDLLDAENHQ AVKKSLQETL ILCASIDPWI QNKLKNKVLS
   481  VYEAPKTNVK AEPTRFQKEP ENPEELTIQD FRLAKLNPLF IAKSITKVGQ KKTPAFPPCC
   541  SKPRKHRPQV IGPWQPRIKK QLRVLAEIAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEATR9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

testis: 9.5 nTPM
spleen: 0.4 nTPM
small intestine: 0.2 nTPM
duodenum: 0.1 nTPM
epididymis: 0.1 nTPM
lung: 0.1 nTPM

Single-cell type

early spermatids: 7.9 nCPM
late spermatids: 4.6 nCPM
late primary spermatocytes: 4.4 nCPM
brain excitatory neurons: 1.4 nCPM
brain inhibitory neurons: 1.2 nCPM
other brain neurons: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
HEAT repeat-containing protein 9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEATR9 as an antibody target. Whether an autoantibody or antibody against HEATR9 could matter depends on whether native HEATR9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEATR9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEATR9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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