Seroatlas · Human Serome Atlas

HEATR6

HEAT repeat-containing protein 6

Also known as: ABC1, FLJ22087, HEAT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6AI08
Gene: HEATR6
Ensembl: ENSG00000068097
Chromosome: 17
Canonical length: 1181 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1181 residues, UniProt reviewed canonical sequence.

>Q6AI08|HEATR6
     1  MAAVQVVGSW PSVQPREAPR EAIPERGNGF RLLSARLCAL RPDDSSSART EIHLLFDQLI
    61  SENYSEGSGV APEDVSALLV QACRLVPLNQ NHLVSKVSQL IHHLLNRLQV IVDEQHLDFL
   121  LAYTISAIHQ CSSWTHREIL QALAALVYCN GSKCQKYLPE LLGNTGLLMK LSDLAQSDPE
   181  VRRAAVHCMA NLCLSVPGQP YLEEPYQNVC FQAFLTILQS PKSSDMDDIT FCMLLQNALK
   241  GIQSLLNGGR MKLTQTDELG ALLAVLKKFM FHGLPGLNIE MPTVLYPTPL PQYDGRTPIK
   301  PQQSESSASR PTLNKKKKSK VKPKKIQQGE EEEKESSGEI EAAPVTGTGR VNLHEGNTWC
   361  PSSLGVQSLP LDGSGAAEKD GVSSSFSSSS WKRVSSSESD FSDAEGGMQS KMRSYQAKVR
   421  QGALVCFLST IKSIEKKVLY GYWSAFIPDT PELGSPQSVS LMTLTLKDPS PKTRACALQV
   481  LSAILEGSKQ FLSVAEDTSD HRRAFTPFSV MIACSIRELH RCLLLALVAE SSSQTVTQII
   541  KCLANLVSNA PYDRLKLSLL TKVWNQIKPY IRHKDVNVRV SSLTLLGAIV STHAPLPEVQ
   601  LLLQQPCSSG LGNSNSATPH LSPPDWWKKA PAGPSLEETS VSSPKGSSEP CWLIRLCISI
   661  VVLPKEDSCS GSDAGSAAGS TYEPSPMRLE ALQVLTLLAR GYFSMTQAYL MELGEVICKC
   721  MGEADPSIQL HGAKLLEELG TGLIQQYKPD STAAPDQRAP VFLVVMFWTM MLNGPLPRAL
   781  QNSEHPTLQA SACDALSSIL PEAFSNLPND RQMLCITVLL GLNDSKNRLV KAATSRALGV
   841  YVLFPCLRQD VIFVADAANA ILMSLEDKSL NVRAKAAWSL GNLTDTLIVN METPDPSFQE
   901  EFSGLLLLKM LRSAIEASKD KDKVKSNAVR ALGNLLHFLQ PSHIEKPTFA EIIEESIQAL
   961  ISTVLTEAAM KVRWNACYAM GNVFKNPALP LGTAPWTSQA YNALTSVVTS CKNFKVRIRS
  1021  AAALSVPGKR EQYGSVDQYA RIWNALVTAL QKSEDTIDFL EFKYCVSLRT QICQALIHLL
  1081  SLASASDLPC MKETLELSGN MVQSYILQFL KSGAEGDDTG APHSPQERDQ MVRMALKHMG
  1141  SIQAPTGDTA RRAIMGFLEE ILAVCFDSSG SQGALPGLTN Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEATR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 8.2 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.2 nTPM
ovary: 5.9 nTPM
adrenal gland: 5.6 nTPM
pituitary gland: 5.6 nTPM
spinal cord: 5.6 nTPM
spleen: 5.5 nTPM

Single-cell type

adrenal medulla cells: 43 nCPM
thyrotrophs: 38 nCPM
sertoli cells: 37 nCPM
pituitary stem cells: 37 nCPM
oligodendrocytes: 36 nCPM
somatotrophs: 32 nCPM

Immune cell

memory B-cell: 8.3 nTPM
myeloid DC: 6 nTPM
non-classical monocyte: 5.7 nTPM
intermediate monocyte: 5.4 nTPM
naive B-cell: 4.3 nTPM
classical monocyte: 3.4 nTPM

Brain region

white matter: 12 nTPM
cerebellum: 11 nTPM
medulla oblongata: 9.6 nTPM
pons: 9.4 nTPM
cerebral cortex: 9.3 nTPM
basal ganglia: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Domain of unknown function DUF4042
HEAT Repeat-containing Protein 6
Domain of unknown function (DUF4042)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEATR6 as an antibody target. Whether an autoantibody or antibody against HEATR6 could matter depends on whether native HEATR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEATR6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEATR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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