Seroatlas · Human Serome Atlas

HEATR4

HEAT repeat-containing protein 4

Also known as: HEAT4_HUMAN, MGC48595

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WZ0
Gene: HEATR4
Ensembl: ENSG00000187105
Chromosome: 14
Canonical length: 1026 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable oxidoreductase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1026 residues, UniProt reviewed canonical sequence.

>Q86WZ0|HEATR4
     1  MTRTQKGKTF LPHCFYQSLP PRLGWGMILN YSKLKGKEEC ASVSSVPMVF FSSQYRLHRK
    61  SQYLKMAAAN LTFSQEVVWQ RGLPSIPYSQ YSFDHLYNTN DIIHTPQIRK ARPQKPVSFK
   121  FLGSSSPLTG DTSLAVKTES SANPEKKLKK SKPASTVREA PRPLIHHPCM HPDMLGRPPS
   181  LDVNLEEREA WLLPPEKEAR AWEATVLEKL NERTARWIQS KRPRRPGASP NKWQSFLRQQ
   241  YDWSHIRDEL TSASDLELLK QLEAEETAEF EDQSVILPPQ EKKKPELLLP VYYRLPSYFQ
   301  QAETVEIMPG NKSTEDIHEK TSLSQPQTQS YFRQVTPRAG KFAYSTDNTF EQEIYFDEVQ
   361  IIHQIGAKRD QIVLENLNRY NKQLSKVFPE TPEKWSAQAI PEASYRPVQG ALRWTALPTP
   421  AKDMLLQVGE KDVPIKTRRL KKQAKSLQED VTWELVVLRR MLKEWKTAWA LIIEWHHETV
   481  ENLLQSLGDL HDDVRIKAIT TCATAALERP RIATSQRDSD KTIQDLPEVL LPALEAALCD
   541  KNAHVRMAAA ICQYAIQSHN PLARNIMQTA LLKGNSVDSW AAAQCLALEG TATYPVIKRI
   601  LHQLFTKKNE DTEEQSYILL SYLSEKTTLI HTMLAVELNS CQWKNRIVAC QAFSRISGNV
   661  CLDMKHKLIQ LMWNDWNKEV RRAAAQALGQ MSLGKEVHDI IRVKLGQGNS QERVEALYLI
   721  GELKLMTAKL LPSFLHCFSD DFTAVRRAAC LAAGALQIRD KMVLECLLNL MQRDPYWKIK
   781  AFAIRALGQI GQVSPELTDL LLWAIHYEES PGVRLEACRS ILALKLQGDR VRDTFLDVLL
   841  LENHDAVLKE MYQTMKILNL GNEGNQEMLQ EIKNRIKTLS QKDLLTHKIL KLEMVMGKVR
   901  EEAKRVYLKP KGEQGPLTLQ TLLQETFQDE MVLPRRPSEV CDTEAVIKPV KPRAPNPWLQ
   961  SSVPGLTTRS KVRSSLVKDL RTSPEKRIAV GPFRSDYPAL YLGKFSERTF FSPIMSSPSG
  1021  KKGAHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEATR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
skin: 3.3 nTPM
retina: 2.7 nTPM
cerebellum: 1.9 nTPM
duodenum: 1.7 nTPM
skeletal muscle: 1.7 nTPM

Single-cell type

late primary spermatocytes: 165 nCPM
early spermatids: 158 nCPM
cardiomyocytes: 142 nCPM
late spermatids: 105 nCPM
adipocytes: 66 nCPM
sertoli cells: 43 nCPM

Immune cell

memory B-cell: 0.5 nTPM
naive B-cell: 0.5 nTPM
naive CD8 T-cell: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 16 nTPM
white matter: 15 nTPM
basal ganglia: 13 nTPM
hippocampal formation: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

oxidoreductase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEATR4 as an antibody target. Whether an autoantibody or antibody against HEATR4 could matter depends on whether native HEATR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEATR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEATR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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