Seroatlas · Human Serome Atlas

HDHD5

Haloacid dehalogenase-like hydrolase domain-containing 5

Also known as: CECR5, HDHD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXW7
Gene: HDHD5
Ensembl: ENSG00000069998
Chromosome: 22
Canonical length: 423 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in glycerophospholipid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9BXW7|HDHD5
     1  MAAWGCVAAL GAARGLCWRA ARAAAGLQGR PARRCYAVGP AQSPPTFGFL LDIDGVLVRG
    61  HRVIPAALKA FRRLVNSQGQ LRVPVVFVTN AGNILQHSKA QELSALLGCE VDADQVILSH
   121  SPMKLFSEYH EKRMLVSGQG PVMENAQGLG FRNVVTVDEL RMAFPLLDMV DLERRLKTTP
   181  LPRNDFPRIE GVLLLGEPVR WETSLQLIMD VLLSNGSPGA GLATPPYPHL PVLASNMDLL
   241  WMAEAKMPRF GHGTFLLCLE TIYQKVTGKE LRYEGLMGKP SILTYQYAED LIRRQAERRG
   301  WAAPIRKLYA VGDNPMSDVY GANLFHQYLQ KATHDGAPEL GAGGTRQQQP SASQSCISIL
   361  VCTGVYNPRN PQSTEPVLGG GEPPFHGHRD LCFSPGLMEA SHVVNDVNEA VQLVFRKEGW
   421  ALE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDHD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

tongue: 52 nTPM
skeletal muscle: 44 nTPM
heart muscle: 43 nTPM
liver: 40 nTPM
adrenal gland: 29 nTPM
duodenum: 25 nTPM

Single-cell type

differentiating spermatogonia: 94 nCPM
monocyte progenitors: 79 nCPM
breast lactating cells: 75 nCPM
cardiomyocytes: 65 nCPM
enteric stem cells: 63 nCPM
esophageal basal cells: 60 nCPM

Immune cell

classical monocyte: 86 nTPM
myeloid DC: 75 nTPM
intermediate monocyte: 57 nTPM
total PBMC: 48 nTPM
MAIT T-cell: 36 nTPM
naive CD4 T-cell: 34 nTPM

Brain region

choroid plexus: 16 nTPM
thalamus: 15 nTPM
cerebral cortex: 13 nTPM
cerebellum: 13 nTPM
medulla oblongata: 13 nTPM
hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

glycerophospholipid biosynthetic process

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

HAD-superfamily hydrolase, subfamily IIA
HAD superfamily
HAD-like superfamily
CDP-alcohol phosphatidyltransferase class-I
Haloacid dehalogenase-like hydrolase
HAD-superfamily hydrolase, subfamily IIA, CECR5

KeywordsUniProt

Signal

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDHD5 as an antibody target. Whether an autoantibody or antibody against HDHD5 could matter depends on whether native HDHD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDHD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDHD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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