HDHD2
Haloacid dehalogenase-like hydrolase domain-containing protein 2
Also known as: DKFZP564D1378, HDHD2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H0R4
- Gene
- HDHD2
- Ensembl
- ENSG00000167220
- Chromosome
- 18
- Canonical length
- 259 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Enables enzyme binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
259 residues, UniProt reviewed canonical sequence.
>Q9H0R4|HDHD2
1 MAACRALKAV LVDLSGTLHI EDAAVPGAQE ALKRLRGASV IIRFVTNTTK ESKQDLLERL
61 RKLEFDISED EIFTSLTAAR SLLERKQVRP MLLVDDRALP DFKGIQTSDP NAVVMGLAPE
121 HFHYQILNQA FRLLLDGAPL IAIHKARYYK RKDGLALGPG PFVTALEYAT DTKATVVGKP
181 EKTFFLEALR GTGCEPEEAV MIGDDCRDDV GGAQDVGMLG ILVKTGKYRA SDEEKINPPP
241 YLTCESFPHA VDHILQHLLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HDHD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 35 nTPM
- cerebellum: 34 nTPM
- midbrain: 34 nTPM
- cerebral cortex: 31 nTPM
- amygdala: 31 nTPM
- hypothalamus: 29 nTPM
Single-cell type
- megakaryocytes: 93 nCPM
- parietal cells: 65 nCPM
- esophageal apical cells: 48 nCPM
- retinal pigment epithelial cells: 38 nCPM
- differentiating spermatogonia: 38 nCPM
- gastric chief cells: 34 nCPM
Immune cell
- NK-cell: 31 nTPM
- memory B-cell: 27 nTPM
- naive CD4 T-cell: 27 nTPM
- naive B-cell: 27 nTPM
- classical monocyte: 25 nTPM
- T-reg: 24 nTPM
Brain region
- cerebellum: 49 nTPM
- white matter: 48 nTPM
- pons: 45 nTPM
- medulla oblongata: 41 nTPM
- thalamus: 38 nTPM
- hypothalamus: 38 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.49
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.4
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HDHD2 as an antibody target. Whether an autoantibody or antibody against HDHD2 could matter depends on whether native HDHD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HDHD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HDHD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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