Seroatlas · Human Serome Atlas

HDGFL3

Hepatoma-derived growth factor-related protein 3

Also known as: Hdgfrp3, HDGR3_HUMAN, HRP-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3E1
Gene: HDGFL3
Ensembl: ENSG00000166503
Chromosome: 15
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be involved in microtubule polymerization; negative regulation of microtubule depolymerization; and neuron projection development. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q9Y3E1|HDGFL3
     1  MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK
    61  DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ AIQQQSSSET EGEGGNTADA
   121  SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY TSKKSSKQSR KSPGDEDDKD CKEEENKSSS
   181  EGGDAGNDTR NTTSDLQKTS EGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDGFL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 17 nTPM
cerebral cortex: 15 nTPM
amygdala: 15 nTPM
hippocampal formation: 13 nTPM
hypothalamus: 13 nTPM
spinal cord: 12 nTPM

Single-cell type

vascular endothelial cells: 228 nCPM
early primary spermatocytes: 221 nCPM
lymphatic endothelial cells: 181 nCPM
late primary spermatocytes: 178 nCPM
differentiating spermatogonia: 167 nCPM
cone photoreceptor cells: 145 nCPM

Immune cell

NK-cell: 1.8 nTPM
eosinophil: 1 nTPM
neutrophil: 0.8 nTPM
basophil: 0.7 nTPM
gdT-cell: 0.5 nTPM
classical monocyte: 0.3 nTPM

Brain region

hypothalamus: 21 nTPM
basal ganglia: 21 nTPM
cerebral cortex: 21 nTPM
cerebellum: 20 nTPM
spinal cord: 20 nTPM
white matter: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.97
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDGFL3 as an antibody target. Whether an autoantibody or antibody against HDGFL3 could matter depends on whether native HDGFL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDGFL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDGFL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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